Autopsy report · NCT01547923

Pre-therapeutic Identification of Dihydropyrimidine Dehydrogenase Gene (DPD) Deficiency for Predicting Toxicity to Fluoropyrimidines

“The study stopped due to a death in the arm control”

The sponsor’s own words in the registry.

Life of this trial

• Registered 3 years 8 months after it had already started.
• Ran for about 4 years 9 months before it stopped.
• 1,142 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Na

Sponsor

Institut Cancerologie de l'Ouest

Sponsor type

University, hospital or other

Conditions

Colorectal Cancer; Intravenous 5 Fluorouracile

Interventions

Blood sample for phenotypic and pharmacogenetic analysis.; Blood sample for phenotypic and pharmacogenetic analysis.

Participants

1,142

Sites

25

Countries

France

Trials that died the same way

• A Phase 2 Study of Velcade™ in Subjects With Relapsed or Refractory Follicular B-Cell Lymphoma
  “An arm closed due to lack of efficacy” (68% match in meaning)
• A Study of Vinflunine Plus Gemcitabine Versus Paclitaxel Plus Gemcitabine in Patients With Advanced Breast Cancer
  “Study was stopped before progressive disease or death of alive subjects.” (65% match in meaning)
• Study of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-641/KEYNOTE-641)
  “The study stopped due to futility” (62% match in meaning)
• Switch to Darunavir/r + Maraviroc Quaque Die in Patients With R5 Tropism by Viral DNA Genotyping (GUSTA)
  “Because a higher rate of virological failures in study versus control arm.” (61% match in meaning)
• A Study to Assess the Safety, Tolerability and Effectiveness of MT-0814 for the Treatment of Age-related Macular Degeneration
  “The study terminated for safety reasons” (60% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.