Autopsy report · NCT01252355

Efficacy and Safety of Teriflunomide in Patients With Relapsing Multiple Sclerosis and Treated With Interferon-beta

“Sponsor decision to prematurely stop the study, not linked to any safety concern.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months before it started.
• Ran for about 2 years 3 months before it stopped.
• 534 participants enrolled.
• Results were posted on the registry 1 year 1 month after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Sanofi

Sponsor type

Industry

Conditions

Multiple Sclerosis Relapse

Interventions

Teriflunomide; Placebo (for teriflunomide); Interferon-beta (IFN-beta)

Participants

534

Sites

185

Countries

Argentina, Australia, Austria, Belgium, Brazil, Canada, Chile, Colombia, Denmark, Estonia, Finland, France and more

Trials that died the same way

• A Study of ARRY-371797 (PF-07265803) in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation
  “The Sponsor terminated the study due to futility. The decision to stop the study was not based on safety concerns.” (84% match in meaning)
• Futibatinib and Pembrolizumab Combination in the Treatment of Advanced or Metastatic Urothelial Carcinoma
  “Sponsor decided to discontinue the study due to strategic considerations and not due to any safety-related concerns.” (84% match in meaning)
• Hero: A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) and Pharmacodynamics (PD) of ION269 in Participants With Down Syndrome (DS) at Risk for Alzheimer's Disease (AD)
  “Sponsor decision to terminate study early. Decision not based on safety concerns.” (84% match in meaning)
• A Study to Investigate Use of Off-the-shelf Natural Killer (NK) Cells (SAR445419) in Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
  “Sponsor decision to cancel trial, not related to safety concern.” (84% match in meaning)
• A Study of Lorcaserin as Adjunctive Treatment in Participants With Dravet Syndrome
  “The study was terminated by Sponsor and the decision was not due to any safety or efficacy reasons.” (80% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.