Autopsy report · NCT01126801

Effects of Estrogen and Hot Flashes on Mood in Postmenopausal Women

“Stopped enrolling subjects due to challenge of identifying eligible participants”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 9 months before it stopped.
• 2 participants enrolled.
• Results were posted on the registry 5 years 6 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Massachusetts General Hospital

Sponsor type

University, hospital or other

Conditions

Menopausal Depression

Interventions

Estradiol; Placebo control

Participants

2

Sites

1

Countries

United States

Trials that died the same way

• The Effect of Macugen in Patients With Chronic, Post-Operative Cystoid Macular Edema
  “Difficulty enrolling eligible subjects” (80% match in meaning)
• Phase 1 Study of Zoledronic Acid in Sickle Cell Disease
  “Ended early due to inability to identify eligible subjects” (75% match in meaning)
• Post Operative Delirium Study
  “Participants were unable to be enrolled” (75% match in meaning)
• Treatment of Chronic Post-Traumatic Headache With OnabotulinumtoxinA
  “Study discontinued due to difficulty in enrolling eligible subjects” (74% match in meaning)
• Evaluation of Dextenza in Patients With Ocular GVHD and Effects on Ocular Surface Disease Outcomes
  “Due to difficulty enrolling subjects whom had not meet the inclusion criteria” (74% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.