Autopsy report · NCT01029925

Dichloroacetate (DCA) in Patients With Previously Treated Metastatic Breast or Non-Small Cell Lung Cancer (NSCL)

“DSMB determined, due to higher than expected risk/safety concerns, study should be closed.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 1 year 11 months before it stopped.
• 7 participants enrolled.
• Results were posted on the registry 4 years 3 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Jonsson Comprehensive Cancer Center

Sponsor type

University, hospital or other

Conditions

Metastatic Breast Cancer; Lung Cancer

Interventions

Dichloroacetate (DCA)

Participants

7

Sites

1

Countries

United States

Trials that died the same way

• Pilot Study of Varenicline (Chantix®) in the Treatment of Friedreich's Ataxia
  “The DSMB recommended that the study be stopped as a result of concerns regarding safety and intolerability and insufficient evidence of efficacy.” (72% match in meaning)
• Placebo Controlled Study of VS-6063 in Subjects With Malignant Pleural Mesothelioma
  “Interim analysis-DSMB stated good safety profile but lack of efficacy” (72% match in meaning)
• Daily Isoniazid to Prevent Tuberculosis in Infants Born to Mothers With HIV
  “Data Safety Monitoring Board (DSMB) recommended stopping study due to futility” (70% match in meaning)
• Cyproheptadine Hydrochloride and Nutritional Supplementation in Treating Young Patients With Weight Loss With Cancer
  “study not feasible with low accrual. DSMB recommended closure” (69% match in meaning)
• A Placebo-Controlled Study of Saracatinib (AZD0530) in Patients With Recurrent Osteosarcoma Localized to the Lung
  “The Data Safety Monitoring Board (DSMB) recommended study termination for slow accrual and futility.” (69% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.