Autopsy report · NCT00718523

Study of Adding AMG 479 to First Line Chemotherapy in Patients With Optimally Debulked Epithelial Ovarian Cancer

“The steering committee of the TRIO014 study has taken the decision to stop the TRIO014 trial.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 6 months before it started.
• Ran for about 5 years 10 months before it stopped.
• 170 participants enrolled.
• Results were posted on the registry 1 year 2 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Translational Research in Oncology

Sponsor type

University, hospital or other

Conditions

Ovarian Neoplasms

Interventions

AMG 479; AMG 479 Placebo

Participants

170

Sites

55

Countries

Canada, France, Germany, Ireland, Israel, Spain, United Kingdom, United States

Trials that died the same way

• Safety of F14 Following Total Knee Replacement
  “Study superseded by alternative Phase 3 trial” (65% match in meaning)
• Study of a Melanoma Vaccine in Stage IIb, IIc, and III Melanoma Patients
  “After interim analysis the study was halted to redesign a pivotal trial.” (62% match in meaning)
• A Clinical Study to Evaluate the Safety, Tolerability, PK, PD, and Efficacy of KBP-089 in Patients With T2DM
  “The trial was planned to be conducted in 4 cohorts but was terminated after completion of Cohort 2 for strategic reasons due to limited PD effects.” (61% match in meaning)
• A Prospective Longitudinal Collection of Subjects Diagnosed With Small Cell Lung Cancer
  “Decision was made by Sponsor to stop the trial.” (60% match in meaning)
• A Study Of PF-06664178 In Patients With Advanced Solid Tumors
  “The study was prematurely discontinued due to a business-related decision on 09-FEB-2016. The decision to terminate the trial was based on the overall results.” (60% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.