Autopsy report · NCT00547911

Augmenting Effects of L-DOPS With Carbidopa and Entacapone

“Study terminated due to contamination droxidopa”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 5 years 6 months before it stopped.
• 14 participants enrolled.
• Results were posted on the registry 1 year 3 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 1, Phase 2

Sponsor

National Institute of Neurological Disorders and Stroke (NINDS)

Sponsor type

US National Institutes of Health

Conditions

Parkinson Disease; Multiple System Atrophy; Autonomic Nervous System Diseases

Interventions

Droxidopa; Carbidopa; Entacapone

Participants

14

Sites

1

Countries

United States

Trials that died the same way

• Safety Study of Bevacizumab (Avastin) With Thoracic Radiation in Non-small Cell Cell Lung Cancer
  “Study terminated due to toxicity” (64% match in meaning)
• A Dose Escalation Trial of PR610 Treating Patients With Solid Tumors
  “Study was prematurely discontinued due to unacceptable toxicity.” (55% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.