Autopsy report · NCT00266812

Safety and Tolerability of Low-Dose Temozolomide During Whole Brain Radiation in Patients With Cerebral Metastases From Non-Small-Cell Lung Cancer (Study P04071)(TERMINATED)

“Patient target could not be reached within the planned timeframe.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 9 months after it had already started.
• Ran for about 2 years 10 months before it stopped.
• 35 participants enrolled.
• Results were posted on the registry 1 year 8 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Merck Sharp & Dohme LLC

Sponsor type

Industry

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

Temozolomide and radiotherapy; Whole brain radiotherapy

Participants

35

Trials that died the same way

• Aldosterone Blockade in Chronic Kidney Disease: Influence on Arterial Stiffness and Kidney Function
  “It was not possible within the time frame to recruit the planned no. of patients.” (73% match in meaning)
• A Trial of the Irradiance Level of Phototherapy for Neonatal Jaundice
  “it was estimated that the recruitment of the planned number of patients could not be completed within further 5 years.” (72% match in meaning)
• Prospective Study of the sensiTVT
  “The recruitment proceeded much slower than expected. The planned number of patients could not be reached within the planned time.” (69% match in meaning)
• Efficacy of Rituximab in Acute Cellular Rejection in Renal Transplant Patients
  “The planned recruitment number of 180 Patient could not been achieved.” (67% match in meaning)
• Ovarian Cancer Treatment With a Liposome Formulated mRNA Vaccine in Combination With (Neo-)Adjuvant Chemotherapy
  “Despite the extension of the original recruitment period, the target number of evaluable patients defined in the study protocol could not be reached and recruitment for the trial was stopped at that point of time.” (66% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.