Autopsy report · NCT00208325

PFC Sigma Fixed and Mobile Knee Study

“The study was terminated at the point the primary endpoint and early milestones were reached and because long term outcomes were available from other sources”

The sponsor’s own words in the registry.

Life of this trial

• Registered 5 years 4 months after it had already started.
• Ran for about 10 years 4 months before it stopped.
• 754 participants enrolled.
• Results were posted on the registry 5 years 10 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 4

Sponsor

DePuy International

Sponsor type

Industry

Conditions

Osteoarthritis, Knee

Interventions

P.F.C Sigma Fixed Bearing total knee system; P.F.C Sigma RP Mobile Bearing knee system

Participants

754

Sites

4

Countries

United Kingdom

Trials that died the same way

• Clinical Observation of Qingwei Huazhuo Decoction (Product: Jinsaiyu) in Improving Children With Precocious Puberty of Phlegm-Dampness Internal Accumulation Type
  “The study was terminated prematurely due to the inapplicability of the primary outcome measure” (82% match in meaning)
• A Clinical Study to Evaluate the Long-term Safety and Tolerability of an Investigational Drug in People With Schizophrenia
  “Study terminated early, main goals achieved” (78% match in meaning)
• Prevention of NAFLD in Hispanic Children
  “Study was terminated due to a lack of funding. Data collection was completed for 12-month outcomes; however, funding limitations prevented follow-up for longer timeframes, and some outcomes were not fully collected.” (77% match in meaning)
• Anti-NY ESO-1 mTCR Peripheral Blood Lymphocytes
  “Due to lack of accrual the study was formally terminated on 01-JUL-2020. Primary Completion and Study Completion Dates have been revised based accordingly based on respective definitions” (76% match in meaning)
• A Study to Evaluate the Efficacy and Safety of Piracetam on Aphasia After Acute Ischemic Cerebral Artery Stroke
  “This study was terminated after a pre-specified interim analysis. Please see Detailed Study Description for further information.” (75% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.