Autopsy report · NCT07500987

Phase I Study of [111In]-FPI-2107 in EGFR Mutation-positive NSCLC

“Early termination was due to insufficient tumor uptake thought to be limited by the binding affinity of EGFR, The termination is not related to any safety or quality concerns.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 3 months before it stopped.
• 6 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

AstraZeneca

Sponsor type

Industry

Conditions

EGFR Mutation-positive NSCLC

Interventions

[111In]-FPI-2107; FPI-2053

Participants

6

Sites

3

Countries

China

Trials that died the same way

• Vaccine Treatment of Kidney Cancer
  “fewer tumors than expected expressed FGF-5, led to end of accrual to cohorts A\&B” (57% match in meaning)
• An Evaluation Of PF-03715455 In Moderate To Severe Uncontrolled Asthma
  “The termination was due to business reasons. No safety or efficacy concerns contributed to the termination of the study” (56% match in meaning)
• Suprachoroidal Injection of Triamcinolone Acetonide With IVT Anti-VEGF in Subjects With Macular Edema Following RVO
  “The early termination is due to the results obtained from the sister study, SAPPHIRE (CLS1003-301), which did not meet the 8-week primary efficacy endpoint.” (56% match in meaning)
• First-in-Human Study of TAK-280 in Participants With Solid Tumors
  “Terminated due to limited anti-cancer activity” (55% match in meaning)
• A Randomized Trial to Study the Safety and Efficacy of EGF Cancer Vaccination in Late-stage (IIIB/IV) Non-small Cell Lung Cancer Patients
  “The early termination is not related to safety/toxicity but to initiate new Phase III with biomarker to enrich population \& to further strengthen OS benefit” (55% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.