Autopsy report · NCT06418711

ICoN-1 Phase 3 Study of the Efficacy and Safety of Treatment With MNKD-101, Clofazimine Inhalation Suspension

“Futility”

The sponsor’s own words in the registry.

Life of this trial

• Registered 4 months before it started.
• Ran for about 1 year 2 months before it stopped.
• 132 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Mannkind Corporation

Sponsor type

Industry

Conditions

MAC Lung Disease; Treatment Refractory MAC Lung Disease; Mycobacterium Infections, Nontuberculous

Interventions

Clofazimine Inhalation Suspension; Placebo

Participants

132

Sites

99

Countries

Australia, Japan, South Korea, Taiwan, United States

Trials that died the same way

• Safety of FMT: OpenBiome Outcomes and Longitudinal Follow-up (STOOL) for Recurrent Clostridium Difficile Infection
  “for futility” (81% match in meaning)
• The Effectiveness of Non-Pyrethroid Insecticide-Treated Durable Wall Liners as a Method for Malaria Control in Endemic Rural Tanzania
  “futility ground” (79% match in meaning)
• Rivaroxaban Post-Transradial Access for the Prevention of Radial Artery Occlusion
  “Assessment for futility” (79% match in meaning)
• Effectiveness of Ranolazine on Reducing Chest Pain in Patients With Blockage But no Stents
  “due to futility” (78% match in meaning)
• Prevention of Unexplained Recurrent Abortion by Enoxaparine
  “Stopped for futility” (75% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.