Autopsy report · NCT06042257

Guanfacine for Hyperactivity in Children With Down Syndrome (HYPEbeGONE_DS)

“Study was stopped after careful review of product manufacturing needs and available resources. Decision reflects consideration of feasibility, enrollment challenges, and overall program goals.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 year 4 months before it started.
• Ran for about 8 months before it stopped.
• 3 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Rachel G. Greenberg, MD, MB, MHS

Sponsor type

University, hospital or other

Conditions

Hyperactivity in Children With Down Syndrome; Impulsivity in Children With Down Syndrome

Interventions

Guanfacine Hydrochloride Immediate Release; Placebo

Participants

3

Sites

14

Countries

United States

Trials that died the same way

• The Safety and Efficacy of a Peanut Immunotherapy Dissolving Film for Peanut Allergy
  “Study product manufacturing suspended due to manufacturing problems, before initiation of study intervention.” (71% match in meaning)
• Nano-Pulse Stimulation (NPS) in Seborrheic Keratosis Optimization Study
  “Study enrollment was halted due to a business decision by the Sponsor to focus resources on other clinical areas outside of dermatology.” (66% match in meaning)
• Nanoparticles and Hypofractionated Protontherapy for Reirradiation of Pantumor Relapse
  “Study prematurely terminated following the decision by industrial partner to withdraw from the project (product supply issue).” (65% match in meaning)
• Efficacy and Safety of Iota-Carrageenan Eye Drops (NCX-4240)
  “Study stopped following management decision” (63% match in meaning)
• Study to Evaluate the Efficacy and Safety of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury
  “Study has been stopped by sponsor decision.” (63% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.