Autopsy report · NCT05643495

A Study to Evaluate Efficacy and Safety of VX-864 in Participants With the PiZZ Genotype

“Study drug dosing was permanently discontinued at the Sponsor's discretion based on frequency and nature of skin and subcutaneous tissue disorders.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 3 months before it started.
• Ran for about 1 year 6 months before it stopped.
• 14 participants enrolled.
• Results were posted on the registry 1 year 1 month after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Vertex Pharmaceuticals Incorporated

Sponsor type

Industry

Conditions

Alpha-1 Antitrypsin Deficiency

Interventions

VX-864

Participants

14

Sites

13

Countries

Germany, Ireland, United Kingdom, United States

Trials that died the same way

• Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth - Endodontics
  “Manufacturer discontinued drug before any participants could be enrolled.” (70% match in meaning)
• A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)
  “The Sponsor terminated the study due to early dose-limiting toxicities.” (67% match in meaning)
• RNA Extraction and Amplification From Biopsy Specimens in Subjects With Metastatic Renal Cell Carcinoma (AGS-NTS-017)
  “The sponsor's clinical program for the agent used in this study was discontinued.” (66% match in meaning)
• Evaluation of Apricoxib (Selective Cyclooxygenase 2 Inhibition) in Modulating T Regulatory Cells of Patients With Early Stage Non-small Cell Lung Cancer
  “Drug sponsor stopped drug manufacture due to toxicity issues from other studies” (66% match in meaning)
• A Dose Escalation Trial of PR610 Treating Patients With Solid Tumors
  “Study was prematurely discontinued due to unacceptable toxicity.” (65% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.