Autopsy report · NCT05207709

Ribociclib vs. Palbociclib in Patients With Advanced Breast Cancer Within the HER2-Enriched Intrinsic Subtype

“The study was prematurely halted because enrollment was significantly delayed compared with the original projections due to the evolving therapeutic landscape.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 3 months before it started.
• Ran for about 4 years before it stopped.
• 61 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

SOLTI Breast Cancer Research Group

Sponsor type

University, hospital or other

Conditions

Metastatic Breast Cancer

Interventions

Ribociclib + Letrozole OR Fulvestrant; Palbociclib + Letrozole OR Fulvestrant; Paclitaxel +/- Tislelizumab

Participants

61

Sites

71

Countries

Portugal, Spain, United States

Trials that died the same way

• Study to Evaluate the Efficacy and Safety of Moxifloxacin Versus Amoxicillin/Clavulanate in the Treatment of Acute Bacterial Rhinosinusitis
  “The study was prematurely terminated due to slow enrollment beyond the planned study timelines.” (79% match in meaning)
• Study of Ombitasvir/Paritaprevir/Ritonavir in Japanese Adults With Genotype 1b Chronic Hepatitis C Virus (HCV) Infection With End Stage Renal Disease (ESRD) on Hemodialysis (HD)
  “Study halted prematurely, prior to enrollment of first participant” (78% match in meaning)
• Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS)
  “This study was stopped prematurely due to lack of enrollment within a 1-5-year period.” (77% match in meaning)
• High Cut Off Dialysis in Systemic Inflammatory Response Syndrome Patients After Cardiac Surgery
  “Study halted prematurely, prior to enrollment of first patient, due to recruiting problems.” (76% match in meaning)
• The Role of Osteopathic Manipulative Medicine in Recovery From Concussions
  “Due to lower than anticipated enrollment number, this study was stopped.” (76% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.