Autopsy report · NCT05192382

A Study to Evaluate the Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (PATHFNDR-2)

“The study was stopped early for business reasons (not due to changes in the benefits or risks of paltusotine).”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 4 years 6 months before it stopped.
• 111 participants enrolled.
• Results were posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Crinetics Pharmaceuticals Inc.

Sponsor type

Industry

Conditions

Acromegaly

Interventions

Paltusotine; Placebo

Participants

111

Sites

57

Countries

Argentina, Brazil, Bulgaria, China, France, Germany, Greece, Hungary, India, Israel, Italy, Poland and more

Trials that died the same way

• Computed Tomography Enterography (CTE) Versus Capsule Endoscopy for Overt, Obscure Gastrointestinal (GI) Bleeding
  “The study was stopped before the first patient was enetered due to logistical issues and lack of funding.” (70% match in meaning)
• An Efficacy and Safety Study of JNJ-26113100 in the Treatment of Adult Atopic Dermatitis
  “The study was stopped due to a non-clinical safety finding.” (70% match in meaning)
• Phase II Study of TPA Plus Dexamethasone & CMT in Hematologic Malignancies
  “Study was terminated early due to lack of experimental medication (supply issues)” (69% match in meaning)
• A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease
  “Study stopped due to business reasons, following full enrollment of the first dose cohort.” (68% match in meaning)
• Inotropic Treatment With Levosimendan (SimdaxR)in Heart Surgery
  “The study was stopped due to difficulties in including patients” (68% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.