Autopsy report · NCT05172596

PHE885 CAR-T Therapy in Adult Participants With Relapsed and Refractory Multiple Myeloma

“The study was terminated since the sponsor made the decision to discontinue further development of the study drug durcabtagene autoleucel (PHE885).”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months before it started.
• Ran for about 3 years 3 months before it stopped.
• 146 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Novartis Pharmaceuticals

Sponsor type

Industry

Conditions

Multiple Myeloma

Interventions

PHE885

Participants

146

Sites

36

Countries

Australia, Brazil, Canada, France, Germany, Greece, Israel, Italy, Japan, Saudi Arabia, Singapore, Spain and more

Trials that died the same way

• Study of Magrolimab Combinations in Patients With Relapsed/Refractory Multiple Myeloma
  “This study was terminated early due to the Sponsor's decision to discontinue development of the investigational drug and close the program.” (78% match in meaning)
• Panobinostat/Velcade in Multiple Myeloma
  “This study was terminated because the drug company stopped making the study drug” (75% match in meaning)
• Cvac as Maintenance Treatment in Patients With Epithelial Ovarian Cancer in Complete Remission Following First-line Chemotherapy or Second-line Treatment
  “The study was terminated due to company restructuring and changes in drug development priorities.” (71% match in meaning)
• Study of Satraplatin (JM-216) in Combination With Docetaxel
  “Sponsor decided to discontinue study drug development.” (70% match in meaning)
• Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease
  “Study was terminated early by the Sponsor due to unblinding between study drug and placebo groups at the subject, site and Sponsor levels.” (70% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.