Autopsy report · NCT04999059

Long-Term Follow-up Study of Subjects With Fabry Disease Who Received Lentiviral Gene Therapy in Study AVRO-RD-01-201

“This study was voluntarily terminated due to a business decision not to proceed, and not due to any safety or efficacy issue.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 years 3 months after it had already started.
• Ran for about 4 years 3 months before it stopped.
• 5 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Sponsor

AVROBIO

Sponsor type

Industry

Conditions

Fabry Disease

Interventions

Safety and Efficacy Assessments

Participants

5

Sites

3

Countries

Australia, Brazil

Trials that died the same way

• Relative Bioavailability Study of Ropinirole Implants in Parkinson's Patients on L-Dopa Switched From Oral Ropinirole
  “This study was terminated for reasons not related to efficacy or safety” (84% match in meaning)
• A Study of TCD601 (Siplizumab) in New Onset Type 1 Diabetes Patients
  “The study has been early terminated due to business reasons. This decision is not related to any safety, efficacy, or regulatory concerns.” (84% match in meaning)
• Efficacy and Safety of GWP42003-P Oral Solution in Children With Epilepsy With Myoclonic-atonic Seizures
  “The study was terminated due to a business decision.” (83% match in meaning)
• Surgical Treatment of Chronic Neuropathic Pain
  “The study was terminated due to lower than expected enrollment. The decision to terminate the study was not based on any safety or efficacy concerns.” (83% match in meaning)
• An Evaluation Of PF-03715455 In Moderate To Severe Uncontrolled Asthma
  “The termination was due to business reasons. No safety or efficacy concerns contributed to the termination of the study” (83% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.