Autopsy report · NCT04959266

A Study to Assess the Effects of Itraconazole, Rifampicin, and Omeprazole on Pharmacokinetics of Adavosertib

“The study terminated because the clinical development programme for Adavosertib has been discontinued”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 11 months before it stopped.
• 5 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

AstraZeneca

Sponsor type

Industry

Conditions

Advanced Solid Tumours

Interventions

Adavosertib; Itraconazole; Rifampicin; Omeprazole

Participants

5

Sites

5

Countries

Spain, United States

Trials that died the same way

• A Phase 1b/2 Study of Safety and Efficacy of Rociletinib in Combination With MPDL3280A in Patients With Advanced or Metastatic EGFR-mutant NSCLC
  “The study terminated before Phase 1 was completed. This study was reprioritized within the rociletinib development program.” (58% match in meaning)
• Inotropic Treatment With Levosimendan (SimdaxR)in Heart Surgery
  “The study was stopped due to difficulties in including patients” (58% match in meaning)
• Open-Label Extension Study of Rufinamide Given as Adjunctive Therapy in Patients With Refractory Partial Seizures
  “The study was terminated early by the sponsor due to the discontinuation of clinical development for rufinamide.” (58% match in meaning)
• Medication Use Among American Indians Adults
  “The study has not been stopped. The study does not qualify as a clinical trial so it was withdrawn from clinicaltrials.gov.” (57% match in meaning)
• Pembrolizumab Plus Lenvatinib in Previously Treated Classic Kaposi Sarcoma
  “The lack of adequate funding has made it impossible to continue with the clinical study As this study was not initiated, no subject was included and no data was collected,thus no result can be obtained SPONSOR\_DECISION End of trial date:15 Oct 2025” (57% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.