Autopsy report · NCT04526912

Treatment and Prevention of Acute Lung Injury (ALI) in Patients With COVID-19 Infection

“Study met predefined futility criteria for efficacy endpoints.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 9 months before it stopped.
• 10 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

Viela Bio

Sponsor type

Industry

Conditions

Acute Lung Injury

Interventions

VIB7734; Placebo

Participants

10

Sites

1

Countries

United States

Trials that died the same way

• Pazopanib in Imatinib Refractory or Intolerant Gastrointestinal Stromal Tumors (GIST)
  “Lack of efficacy - Futility endpoint reached” (83% match in meaning)
• A Dose Finding Study to Investigate the Safety and Effectiveness of GSK1070806 in Adult Participants With Moderate to Severe Atopic Dermatitis
  “Sponsor decision to early terminate the study based on the pre-defined futility criterion for efficacy. No safety concerns were identified.” (79% match in meaning)
• A Study of Idasanutlin With Cytarabine Versus Cytarabine Plus Placebo in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)
  “The study was stopped for futility based on efficacy results at the interim analysis; no unexpected safety findings were observed.” (76% match in meaning)
• Avelumab in Previously Untreated Patients With Epithelial Ovarian Cancer (JAVELIN OVARIAN 100)
  “The study was terminated based on the results of a planned interim analysis that showed futility of efficacy.” (73% match in meaning)
• Direct Lysis of Staph Aureus Resistant Pathogen Trial of Exebacase
  “The independent DSMB recommended that the study be stopped for futility following interim efficacy analysis.” (72% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.