Autopsy report · NCT04032717

Griffithsin-based Rectal Microbicide for PREvention of Viral ENTry (PREVENT)

“Due to the COVID-19 pandemic, study enrollment has been prematurely terminated.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 3 months before it started.
• Ran for about 1 year 7 months before it stopped.
• 18 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

Rhonda Brand

Sponsor type

University, hospital or other

Conditions

HIV Prevention

Interventions

Q-Griffithsin (Q-GRFT) enema; Placebo enema

Participants

18

Sites

1

Countries

United States

Trials that died the same way

• Changing Developmental Trajectories Through Early Treatment
  “Participant enrollment was hindered by the COVID-19 pandemic and the study was ultimately terminated.” (82% match in meaning)
• Treatment Resistance Following Anti-cancer Therapies
  “Study terminated due to lack of enrollment that has been compounded by the global COVID-19 pandemic. There were no safety and/or efficacy concerns involved in the decision to stop enrollment.” (82% match in meaning)
• Oral Immunotherapy for Desensitization in Children, Adolescents, and Young Adults With Hen Egg Allergy
  “The study was prematurely terminated by the Sponsor based on difficulties in meeting enrollment goals, especially during the COVID-19 pandemic, and not for reasons relating to any concerns regarding quality, safety, or efficacy.” (81% match in meaning)
• Impact of App Based Diabetes Training Program in Conjunction With the BD Nano Pen Needle in People With T2 Diabetes
  “Enrollment halted prematurely due to the Covid-19 pandemic” (80% match in meaning)
• Study to Evaluate the Efficacy and Safety of Moxifloxacin Versus Amoxicillin/Clavulanate in the Treatment of Acute Bacterial Rhinosinusitis
  “The study was prematurely terminated due to slow enrollment beyond the planned study timelines.” (78% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.