Autopsy report · NCT03725267

Melatonin for Renal Protection in Patients Receiving Polymyxin B

“Due to COVID 19 pandemic social isolation measures, we had to stop recruting hospitalized patients.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 2 years 9 months before it stopped.
• 88 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Hospital de Clinicas de Porto Alegre

Sponsor type

University, hospital or other

Conditions

Acute Kidney Injury; Melatonin; Polymyxin B Adverse Reaction

Interventions

Melatonin Pill; Placebo oral capsule

Participants

88

Sites

2

Countries

Brazil

Trials that died the same way

• The Norwegian Prednisolone in Early Psychosis Study
  “Stopped because of COVID 19 pandemic” (72% match in meaning)
• Assessing Physical Activity Levels of Patients Following HTO.
  “Halting of all research and elective surgeries due to the Covid-19 pandemic” (68% match in meaning)
• Tobacco Cessation for Sexual Minorities
  “Covid-19 quarantines and closures prevented recruitment and assessment of participants.” (68% match in meaning)
• Improving 24-hour Blood Pressure in Obstructive Sleep Apnea
  “Covid-19 Pandemic prevented this study from beginning” (67% match in meaning)
• Effect of a Lifestyle Intervention on Nutritional Status and Prognosis of Endometrial Cancer Survivors
  “Study stopped due to COVID-19 pandemic, as conducting a behaviour-change programme in groups was not recommended to prevent the spread of the virus.” (67% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.