Autopsy report · NCT03652571

Nortriptyline for the Treatment of Functional Dyspepsia

“The inclusion of participants went more difficult than initially thought. Preliminary analysis showed that the difference between the groups was great enough to draw conclusions from it, so the trial is terminated prematurely.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 5 years 11 months before it stopped.
• 96 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Maastricht University Medical Center

Sponsor type

University, hospital or other

Conditions

Functional Dyspepsia

Interventions

Nortriptyline; Placebo

Participants

96

Sites

14

Countries

Netherlands

Trials that died the same way

• Endoscopic Full Thickness Resection of Gastric Subepithelial Tumors (FROST)
  “According to study protocol the trial was terminated because the recruitment of trial participants was insufficient.” (74% match in meaning)
• Impact of Molecular Testing on Improved Diagnosis, Treatment and Management of CAP
  “The trial was stopped earlier than planned after an ad hoc interim analysis” (72% match in meaning)
• A Study of Plitidepsin in Patients With Relapsed or Refractory Angioimmunoblastic T-cell Lymphoma
  “The main reason that motivated the study termination was the slow recruitment of the trial.” (70% match in meaning)
• An Efficacy and Safety Study of Lanabecestat (LY3314814) in Early Alzheimer's Disease
  “An independent assessment concluded the trial was not likely to meet the primary endpoint upon completion and therefore, trial stopped for futility” (70% match in meaning)
• A Study to Learn About the Study Medicine (Nirmatrelvir Plus Ritonavir) in Pregnant Women With COVID-19
  “The trial prematurely terminated due to the inability to recruit the planned number of subjects. The decision to terminate the trial was not based on any safety concerns.” (69% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.