Autopsy report · NCT03197025

Immunotherapy With E6 T Cell Receptor (TCR) T Cells for Vulvar High-Grade Squamous Intraepithelial Lesions

“The study was closed due to investigator discretion based on the lack of perceived clinical activity observed in the study.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 7 months before it started.
• Ran for about 2 years 9 months before it stopped.
• 1 participant enrolled.
• Results were posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

National Cancer Institute (NCI)

Sponsor type

US National Institutes of Health

Conditions

Human Papillomavirus; HPV-16; High Grade Squamous Intraepithelial Lesion

Interventions

Aldesleukin; E6 T Cell Receptor (TCR)

Participants

1

Sites

1

Countries

United States

Trials that died the same way

• Clinical Trial of Evaluating TQB3912 Tablets Combined With Fulvestrant Injection±TQB3616 Capsules for Locally Advanced or Metastatic Hormone Receptor(HR)-Positive and Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Breast Cancer
  “This study was closed due to business reasons. Closure was not prompted by any safety or efficacy concerns.” (77% match in meaning)
• A Study of Alectinib in RET-rearranged Non-small Cell Lung Cancer or RET-mutated Thyroid Cancer
  “Study closed due to slow accrual and lack of efficacy.” (76% match in meaning)
• Exenatide For Reducing the Reinforcing Effects of Cocaine
  “The study was closed due to the inability to acquire the study drug.” (72% match in meaning)
• Reiki for the Management of Neuropathic Pain
  “Study closed due to substantial decrease in the desired patient population.” (71% match in meaning)
• Study of Heart Failure Hospitalizations After Aquapheresis Therapy Compared to Intravenous (IV) Diuretic Treatment
  “Closed due to patient recruitment challenges. No interim analyses were completed; study closure was not related to any concerns about safety or futility.” (71% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.