Autopsy report · NCT02684071

Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors

“Lack of additional funding; patients (3) no longer receiving intervention.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 3 years 10 months before it stopped.
• 3 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Nicklaus Children's Hospital f/k/a Miami Children's Hospital

Sponsor type

University, hospital or other

Conditions

Recurrent Childhood Medulloblastoma; Recurrent Childhood Ependymoma; Childhood Atypical Teratoid/Rhabdoid Tumor; Embryonal Tumor With Abundant Neuropil and True Rosettes; Metastatic Malignant Neoplasm to the Leptomeninges

Interventions

Intra thecal methotrexate; topotecan; cyclophosphamide

Participants

3

Sites

1

Countries

United States

Trials that died the same way

• Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid
  “Inadequate patients recruited. Completion of funding” (78% match in meaning)
• AIDI - Research & Development of a Multisensor-Based Machine Learning Technology for Real-Time Automated Detection of COVID-19 Decompensation
  “No eligible patients could be found and funding was lost” (77% match in meaning)
• Effectiveness Assessment of Riluzole in the Prevention of Oxaliplatin-induced Peripheral Neuropathy.
  “Lack of treatment, sponsor decision.” (74% match in meaning)
• Non-alcoholic Fatty Liver Disease (NAFLD) in HIV: The Role of Nutritional Interventions
  “Not enough eligible patients available” (70% match in meaning)
• Endothelial Protection in Convalescent COVID-19 Patients
  “Lack of the eligible patients” (70% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.