Autopsy report · NCT02577029

Study of ARC-520 With or Without Other Drugs Used in the Treatment of Chronic Chronic Hepatitis B Virus (HBV)

“Company decision to discontinue trial”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months before it started.
• Ran for about 1 year before it stopped.
• 79 participants enrolled.
• Results were posted on the registry 2 years 4 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Arrowhead Pharmaceuticals

Sponsor type

Industry

Conditions

Hepatitis B; Hepatitis D

Interventions

ARC-520; entecavir; pegylated interferon alpha 2a; tenofovir disoproxil; antihistamine

Participants

79

Sites

33

Countries

Australia, Bulgaria, China, Moldova, New Zealand, South Korea, Taiwan, Thailand

Trials that died the same way

• One Touch® Verio®IQ European Clinical Outcomes Study
  “Business decision to withdraw trial” (85% match in meaning)
• A Safety and Tolerability Study of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pneumonia
  “Trial terminated early per business decision” (81% match in meaning)
• Study of Inlexisertib (DCC-3116) in Participants With RAS/MAPK Pathway Mutant Solid Tumors
  “Trial terminated due to business decision, not based on any safety or efficacy concerns.” (78% match in meaning)
• Regorafenib-pembrolizumab vs. TACE/TARE in Intermediate Stage HCC Beyond Up-to-7
  “The trial ended earlier than planned due to slow enrolment, which has made it unfeasible to achieve the target sample size within a reasonable timeframe. Consequently, a business decision has been made to discontinue funding for the trial.” (78% match in meaning)
• A Study to Learn About the Effect of Avelumab First-Line Maintenance in Canadian People With Advanced Bladder Cancer
  “The trial was terminated for strategic reasons. The decision was not based on any safety and/or efficacy concerns.” (77% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.