Autopsy report · NCT02438761

PF-05212384 (PKI-587) for t-AML/MDS or de Novo Relapsed or Refractory Acute Myeloid Leukemia (AML) (LAM-PIK)

“No objective response was observed at the first step. The treatment was considered ineffective, with a complete clinical trial suspension.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 4 months before it started.
• Ran for about 2 years 8 months before it stopped.
• 10 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Institut Curie

Sponsor type

University, hospital or other

Conditions

Therapy-related Acute Myeloid Leukemia and Myelodysplastic Syndrome; Acute Myeloid Leukemia, in Relapse; de Novo Acute Myeloid Leukemia at Diagnostic

Interventions

PF-05212384

Participants

10

Sites

5

Countries

France

Trials that died the same way

• A Pilot Study of Candesartan as a Treatment for Cocaine Dependence
  “Results of interim efficacy analysis showed results were not promising.” (66% match in meaning)
• A Study of Panobinostat (LBH589) as Second-Line Therapy in Patients With Chronic Graft-Versus-Host Disease
  “A decision was made to not move forward with the study. No participants were enrolled or treated.” (64% match in meaning)
• Hydroxyurea in Primary Progressive Multiple Sclerosis
  “No efficacy (interim.analysis)” (63% match in meaning)
• Efficacy, Safety and Tolerability of AG013 in Oral Mucositis Compared to Placebo When Administered Three Times Per Day
  “No efficacy could be demonstrated, sponsor decided to prematurely end the study.” (63% match in meaning)
• Web-Based Coping and Communication Skills Intervention in Improving Psychological Adaptation in Patients With Gynecological Cancer
  “The study was never initiated, no patients were enrolled. It has been closed with the IRB.” (62% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.