Autopsy report · NCT02409238

Insulin Resistance and Mild Cognitive Impairment (IRMCI) Study

“1. Limits of grant funding reached 2. A/Prof Ng Tze Pin (P.I. \& holder of NMRC Grant (CIRG12may033) funding this study) retired in Aug 2022. 3. Resignations of staff and collaborators especially over the 1st 2 years of the COVID-19 pandemic”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 4 years 10 months before it stopped.
• 105 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 4

Sponsor

SingHealth Polyclinics

Sponsor type

University, hospital or other

Conditions

Mild Cognitive Impairment; Insulin Resistance; Diabetes Mellitus, Type 2

Interventions

Metformin; Intensive Lifestyle Intervention; Standard LIfestyle Recommendation

Participants

105

Sites

1

Countries

Singapore

Trials that died the same way

• Brain Effect of Vagal Nerve Stimulation at Rest and Pain
  “There was a serious delay in the study due to the COVID pandemic. So the grant period was over.” (69% match in meaning)
• Testing the Implementation of Movement-to-Music in a Community Fitness Center and Blended Onsite and Teleexercise Class
  “Grant projects were revised in response to COVID-19.” (69% match in meaning)
• High Risk Outpatient Intern-led Care (HeROIC) Clinic Initiative
  “Covid-19, funding” (67% match in meaning)
• Smoking Reduction: Testing a Novel Approach to Cessation in Primary Care Practice Settings
  “Funding was withdrawn in January 2020. Covid-19 pandemic prevented the study from continuing to a point where it would need to be restarted. Multiple participants dropped out throughout pandemic.” (67% match in meaning)
• RESIST-2: 2nd-line ART for HIV-2 Infection
  “COVID-19 and Funding” (67% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.