Autopsy report · NCT02408016

Genetically Modified T Cells in Treating Patients With Stage III-IV Non-small Cell Lung Cancer or Mesothelioma

“Terminated due to loss of funding”

The sponsor’s own words in the registry.

Life of this trial

• Registered 2 months before it started.
• Ran for about 5 years 1 month before it stopped.
• 11 participants enrolled.
• Results were posted on the registry 1 year 2 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 1, Phase 2

Sponsor

Fred Hutchinson Cancer Center

Sponsor type

University, hospital or other

Conditions

Advanced Pleural Malignant Mesothelioma; HLA-A*0201 Positive Cells Present; Recurrent Non-Small Cell Lung Carcinoma; Recurrent Pleural Malignant Mesothelioma; Stage III Non-Small Cell Lung Cancer AJCC v7; Stage III Pleural Malignant Mesothelioma AJCC v7

Interventions

Aldesleukin; Autologous WT1-TCRc4 Gene-transduced CD8-positive Tcm/Tn Lymphocytes; Cyclophosphamide; Laboratory Biomarker Analysis; Therapeutic Conventional Surgery

Participants

11

Sites

1

Countries

United States

Trials that died the same way

• Localized Radiation Therapy or Recombinant Interferon Beta and Avelumab With or Without Cellular Adoptive Immunotherapy in Treating Patients With Metastatic Merkel Cell Carcinoma
  “Terminated due to loss in funding” (99% match in meaning)
• IGFBP-2 Vaccine and Combination Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Undergoing Surgery
  “Terminated due to lack of funding” (95% match in meaning)
• Sirolimus, Docetaxel, and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate Cancer
  “Terminated due to insufficient funding” (93% match in meaning)
• The Effects of Different Long-acting Bronchodilator Medications on Asthma Patients With Different Genetic Variations
  “Funding was terminated” (90% match in meaning)
• Closed-loop Control of Postprandial Glucose Levels in Children and Adults With Type 1 Diabetes
  “Funding terminated” (87% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.