Autopsy report · NCT02140112

Efficacy and Safety of Trichuris Suis Ova (TSO) as Compared to Placebo in Autism Spectrum Disorder

“A preliminary analysis of data from this trial failed to demonstrate any signal of activity.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 11 months before it stopped.
• 23 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Coronado Biosciences, Inc.

Sponsor type

Industry

Conditions

Autism

Interventions

Trichuris suis ova; Placebo

Participants

23

Sites

5

Countries

United States

Trials that died the same way

• A Phase III Trial of ZD4054 (Zibotentan) (Endothelin A Antagonist) in Non-metastatic Hormone Resistant Prostate Cancer
  “early efficacy review by the Independent Data Monitoring Committee indicated it was unlikely to meet its primary efficacy endpoints” (57% match in meaning)
• A Study to Evaluate the Effects of GLPG2737 in Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
  “The study was early terminated due to lack of efficacy.” (57% match in meaning)
• Zuni Health Initiative - Chronic Disease Education
  “This is not a clinical trial and was inadvertently entered into the system.” (57% match in meaning)
• Venetoclax and Quizartinib in Treating Patients With FLT3-mutated Recurrent or Refractory Acute Myeloid Leukemia
  “This study was terminated early due to other competing trials, therefore did not go on to the Phase II portion of the study.” (56% match in meaning)
• A Study With BPS-314d-MR-PAH-303 in Participants With Pulmonary Arterial Hypertension
  “The pivotal study, BPS-314d-MR-PAH-302 (NCT01908699), failed to demonstrate efficacy.” (56% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.