Autopsy report · NCT02051218

Prevention of Symptomatic Skeletal Events With Denosumab Administered Every 4 Weeks Versus Every 12 Weeks

“Board decision as by March 2026, the number of patients undergoing treatment decreased to around 50, from the total 1,380 patients enrolled in the trial. And due to price changes in medication”

The sponsor’s own words in the registry.

Life of this trial

• Registered 6 months before it started.
• Ran for about 11 years 8 months before it stopped.
• 1,380 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Swiss Cancer Institute

Sponsor type

University, hospital or other

Conditions

Metastatic Breast Cancer; Metastatic Prostate Cancer; Bone Metastases

Interventions

Denosumab (reduced dosing); Denosumab (standard dosing)

Participants

1,380

Sites

50

Countries

Austria, Germany, Switzerland

Trials that died the same way

• An Efficacy, Safety, Tolerability and Pharmacokinetics Study of 12 Weeks Treatment With Simeprevir and Daclatasvir in Participants With Chronic Hepatitis C Virus Genotype 1b or 4 Infection and Either Severe Renal Impairment or End-stage Renal Disease on Hemodialysis.
  “Trial has been cancelled due to availability of new therapeutic options for patient population” (65% match in meaning)
• Adjuvant Chemotherapy With S-1 Plus Oxaliplatin Versus S-1 Alone in Locally Advanced Gastric Cancer
  “The number of patients enrolled was much less than expected” (65% match in meaning)
• Safety, Tolerability, Pharmacokinetics, and Antitumor Study of ADCT-601 to Treat Advanced Solid Tumors
  “Change in clinical plan and drug supply” (64% match in meaning)
• Effect of Citalopram on Chest Pain in Patients With Functional Chest Pain
  “The clinical trial has ended prematurely due to low patient recruitment” (61% match in meaning)
• Evaluation of the Cryopreserved Amniotic Membranes in the Care of Resistant Vascular Ulcers
  “clinical trial have encountered difficulties enrolling a sufficient number of patients” (61% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.