Autopsy report · NCT01678820

A Study of the Efficacy and Safety of MK-0431D (a Fixed-dose Combination of Sitagliptin and Simvastatin) for the Treatment of Participants With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Metformin Monotherapy (MK-0431D-266)

“Merck terminated the study for business reasons in November 2013.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 month before it started.
• Ran for about 1 year 1 month before it stopped.
• 299 participants enrolled.
• Results were posted on the registry 1 year after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Merck Sharp & Dohme LLC

Sponsor type

Industry

Conditions

Type 2 Diabetes Mellitus

Interventions

Sitagliptin/Simvastatin FDC; Sitagliptin; Simvastatin; Placebo to sitagliptin; Placebo to simvastatin; Placebo to Sitagliptin/Simvastatin FDC

Participants

299

Trials that died the same way

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  “The study was terminated due to strategic business reasons.” (69% match in meaning)
• Study To Determine The Pharmacokinetics Of Sulfasalazine In Children With Juvenile Idiopathic Arthritis
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• Efficacy and Safety of GWP42003-P Oral Solution in Children With Epilepsy With Myoclonic-atonic Seizures
  “The study was terminated due to a business decision.” (68% match in meaning)
• Mechanisms of Interferon Gamma-primed Mesenchymal Stromal Cells (MSCs) for Moderate-to-severe Persistent Asthma
  “The study terminated due to funding ending.” (68% match in meaning)
• Randomized Controlled Study to Incentivize Doctors for Appropriate Use of Medical Care in NL
  “The study was terminated due to logistical reasons” (67% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.