Autopsy report · NCT01598792

Safety Study of Recombinant Listeria Monocytogenes(Lm)Based Vaccine Virus Vaccine to Treat Oropharyngeal Cancer

“Patient 2 suffered DLT post-vaccination. The vaccine manufacturers withdrew support for the study on commercial grounds.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 3 months after it had already started.
• Ran for about 2 years 9 months before it stopped.
• 2 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 1

Sponsor

University of Liverpool

Sponsor type

University, hospital or other

Conditions

HPV-16 +ve Oropharyngeal Carcinoma

Interventions

ADXS11-001

Participants

2

Sites

4

Countries

United Kingdom

Trials that died the same way

• Study to Evaluate the Immune Response and the Safety of Fluarix TM/ Influsplit SSW® 2010/2011 or Pandemrix TM
  “The study was terminated for logistic reasons not related to safety or efficacy of the vaccine.” (62% match in meaning)
• Safety and Immune Response of One-Dose of Candidate H1N1 Influenza Vaccine GSK2340274A in Adults
  “Study was cancelled before enrolment for reasons not related to vaccine safety or efficacy.” (57% match in meaning)
• Personalized Tumor Vaccine Strategy and PD-1 Blockade in Patients With Follicular Lymphoma
  “Vaccine manufacturing has been suspended” (56% match in meaning)
• Peptide Vaccination Associated With Tumoral Immunomodulation in Patients With Advanced Metastatic Melanoma
  “Completion after 2 patients then stop due to end of validity of vaccine peptide” (56% match in meaning)
• Evaluation of Immunogenicity and Safety of DTPa-IPV/Hib Conjugate Vaccine (Infanrix™-IPV/Hib) Administered at 6, 10 and 14 Weeks in Healthy Indian Infants
  “The study is cancelled due to reassessment of the medical need for the vaccine in India. Cancellation is not related to vaccine's safety and/or efficacy.” (55% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.