Autopsy report · NCT01499355

BIIB023 Proof-of-Concept Study in Participants With Lupus Nephritis

“Results from pre-specified criteria did not demonstrate sufficient efficacy to warrant continuation of the study.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 8 months before it started.
• Ran for about 3 years 5 months before it stopped.
• 276 participants enrolled.
• Results were posted on the registry 1 year 1 month after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Biogen

Sponsor type

Industry

Conditions

Lupus Nephritis

Interventions

BIIB023; Placebo; mycophenolate mofetil; oral corticosteroids

Participants

276

Sites

58

Countries

Argentina, Australia, Belgium, Brazil, Colombia, France, Germany, Hong Kong, Hungary, Italy, Malaysia, Mexico and more

Trials that died the same way

• Anecortave Acetate Injection to Treat Steroid-responsive Intraocular Pressure Increase in Cornea Transplant Patients
  “Preliminary data analysis showed insufficient efficacy to justify continuation.” (77% match in meaning)
• A Pilot Study of Candesartan as a Treatment for Cocaine Dependence
  “Results of interim efficacy analysis showed results were not promising.” (74% match in meaning)
• A Study of LY3405105 in Participants With Advanced Cancer
  “The study was terminated for lack of sufficient efficacy.” (73% match in meaning)
• Efficacy and Tolerability of Deucravacitinib in the Management of Palmoplantar Pustulosis
  “Terminated early due to lack of expected efficacy. Three participants were enrolled but none completed the study.” (72% match in meaning)
• Oral EPI-7386 in Patients with Castration-Resistant Prostate Cancer
  “Study was terminated early due to a lack of improved efficacy.” (71% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.