Autopsy report · NCT01437826

Antioxidant Supplement and Reduction of Metachronous Adenomas of the Large Bowel: a Double Blind Randomized Trial

“50% of eligible patients refused to enter the study”

The sponsor’s own words in the registry.

Life of this trial

• Registered 23 years 6 months after it had already started.
• Ran for about 8 years 3 months before it stopped.
• 411 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy

Sponsor type

University, hospital or other

Conditions

Colorectal Adenomas

Interventions

antioxidants; placebo

Participants

411

Sites

1

Countries

Italy

Trials that died the same way

• A Comparison of Gastric pH Control With High Dose Intravenous or Oral Esomeprazole
  “No suitable patients and many patients refused the study” (81% match in meaning)
• Midfoot Fusion Bolt (MFB) in the Early Stage of Diabetic-neuropathic Charcot Feet
  “The study was stopped because there were not enough eligible patients to complete the study.” (70% match in meaning)
• Physio PCI: Impact of Coronary Angioplasty on Non-hyperaemic Pressure Ratio in Patients With Coronary Artery Disease
  “Due to COVID-19 pandemic site refused to include patients in the study” (70% match in meaning)
• Effects of Levothyroxine Treatment on Hemodynamic and Renal Functions in Subclinical Hypothyroidism
  “No patient corresponding to inclusion criteria couldn't be enrolled in the study” (69% match in meaning)
• Crossover Evaluation of Effect of Atorvastatin on PK of Irinotecan in CRC Patients Receiving FOLFIRI
  “Study was withdrawn due to lack of patient enrollment.” (69% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.