Autopsy report · NCT01206166

Trial of Supplemental Parenteral Nutrition in Under and Over Weight Critically Ill Patients (TOP-UP)

“Low enrollment rates.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 9 months before it started.
• Ran for about 4 years 1 month before it stopped.
• 125 participants enrolled.
• Results were posted on the registry 5 years 8 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Clinical Evaluation Research Unit at Kingston General Hospital

Sponsor type

University, hospital or other

Conditions

Critical Illness; Acute Respiratory Failure

Interventions

Olimel (5.7%E / N9E)

Participants

125

Sites

12

Countries

Belgium, Canada, France, United States

Trials that died the same way

• A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning From Mechanical Ventilation
  “Low enrollment rate.” (98% match in meaning)
• Targeted Pharmacological and Behavioral Treatments for Smoking in Schizophrenia Study 1
  “Low rate of enrollment” (92% match in meaning)
• The COVID-19 VaccinE Response and Co-Administration in Rheumatology Patients (COVER-CoAd)
  “Low enrollment.” (91% match in meaning)
• Pre-Treatment of Highly Suspicious Pigmented Skin Lesions With Interleukin-2
  “Low enrollment numbers.” (89% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.