Autopsy report · NCT01055067

ARQ 197 for Participants With Relapsed or Refractory Germ Cell Tumors

“The study was terminated early for futility according to the stopping rule of the Simon 2-stage design.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 1 year 10 months before it stopped.
• 27 participants enrolled.
• Results were posted on the registry 8 years 9 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 2

Sponsor

Daiichi Sankyo

Sponsor type

Industry

Conditions

Non-CNS Germ Cell Tumors (Seminomas and Nonseminomas)

Interventions

Tivantinib (ARQ 197)

Participants

27

Sites

10

Countries

France, United Kingdom, United States

Trials that died the same way

• Efficacy and Safety of MK-7622 as Adjunct Therapy in Participants With Alzheimer's Disease (MK-7622-012)
  “Stage 1 interim analysis of efficacy met the criteria for early trial termination (futility). The trial was terminated at Stage 1; did not proceed to Stage 2.” (66% match in meaning)
• Tissue Adhesive vs. Sterile Strips After Cesarean Delivery
  “Based on results of an interim analysis, the study was halted for futility” (61% match in meaning)
• Comparison of Direct Laryngoscopy, Truview EVO2 and Glidescope in Pediatric Patients
  “The study was stopped for futility at the first interim analysis” (61% match in meaning)
• Minocycline for the Treatment of Decreased Mental Function in HIV-Infected Adults
  “This study was terminated early due to futility.” (61% match in meaning)
• Trial Investigating the Efficacy and Safety of SCH 900435 (Org 25935) in Relapse Prevention in Participants With Alcohol Dependence (P05718)
  “Based on the outcome of a planned interim analysis, the study was stopped early due to futility.” (61% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.