Autopsy report · NCT01047319

A Study to Evaluate the Long-term Safety, Tolerability and Effect of Daily Oral Laquinimod 0.6 mg on Disease Course in Subjects With Relapsing Multiple Sclerosis

“Sponsor terminated RRMS studies as sufficient long term clinical data was collected for the study drug in the relevant dose”

The sponsor’s own words in the registry.

Life of this trial

• Registered 5 months before it started.
• Ran for about 7 years 1 month before it stopped.
• 1,047 participants enrolled.
• Results were posted on the registry 1 year 6 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Teva Branded Pharmaceutical Products R&D, Inc.

Sponsor type

Industry

Conditions

Relapsing Multiple Sclerosis

Interventions

Laquinimod

Participants

1,047

Sites

144

Countries

Bulgaria, Croatia, Czechia, Estonia, Georgia, Germany, Israel, Italy, Lithuania, North Macedonia, Poland, Romania and more

Trials that died the same way

• A Study of THE-630 in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)
  “The Sponsor terminated the study due to early dose-limiting toxicities.” (67% match in meaning)
• Vorinostat and Concurrent Whole Brain Radiotherapy for Brain Metastasis
  “Sponsor stops to provide the study drug.” (64% match in meaning)
• Panobinostat/Velcade in Multiple Myeloma
  “This study was terminated because the drug company stopped making the study drug” (63% match in meaning)
• Study of Magrolimab Combinations in Patients With Relapsed/Refractory Multiple Myeloma
  “This study was terminated early due to the Sponsor's decision to discontinue development of the investigational drug and close the program.” (62% match in meaning)
• Evaluation of Apricoxib (Selective Cyclooxygenase 2 Inhibition) in Modulating T Regulatory Cells of Patients With Early Stage Non-small Cell Lung Cancer
  “Drug sponsor stopped drug manufacture due to toxicity issues from other studies” (62% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.