Autopsy report · NCT00911326

Evaluation of Sentinel Lymph Nodes in Head and Neck Squamous Cell Carcinoma

“The trial was terminated early based on an interim review by the Data and Safety Monitoring Committee for positive efficacy outcome and no safety concerns.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 4 years 3 months before it stopped.
• 101 participants enrolled.
• Results were posted on the registry 1 year after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Navidea Biopharmaceuticals

Sponsor type

Industry

Conditions

Head and Neck Squamous Cell Carcinoma (HNSCC)

Interventions

Lymphoseek

Participants

101

Sites

13

Countries

United States

Trials that died the same way

• Efficacy and Safety of MK-7622 as Adjunct Therapy in Participants With Alzheimer's Disease (MK-7622-012)
  “Stage 1 interim analysis of efficacy met the criteria for early trial termination (futility). The trial was terminated at Stage 1; did not proceed to Stage 2.” (77% match in meaning)
• Acute Effects Of Donepezil On Brain Perfusion And Memory In Subjects With Cognitive Impairment And Mild Alzheimer's Disease
  “The study was terminated because of slow enrollment. The decision to terminate the trial was not based on any safety or efficacy concerns.” (76% match in meaning)
• To Assess the Safety, Tolerability and Pharmacokinetics of ACH-000029 in Healthy Subjects
  “Based on the unblinded clinical data, the trial was terminated.” (76% match in meaning)
• Neoadjuvant Lu-PSMA Radioligand Therapy and Ipilimumab in Men With Very High-risk Prostate Cancer
  “The clinical trial has been terminated due to the revocation of funding. Although one subject was enrolled, the participant withdrew prior to receiving any treatment. No trial-related procedures generating evaluable clinical data were performed.” (75% match in meaning)
• A Dose-finding Study of CC-90009 in Subjects With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher-risk Myelodysplastic Syndromes
  “Trial terminated because of lack of efficacy in the short term acute phase.” (75% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.