Autopsy report · NCT00499369

Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic Colorectal Cancer That Progressed During First-Line Therapy

“Due to inadequate accrual, study was terminated and limited outcome data was reported.”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 5 years 5 months before it stopped.
• 72 participants enrolled.
• Results were posted on the registry 1 year 2 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

National Cancer Institute (NCI)

Sponsor type

US National Institutes of Health

Conditions

Recurrent Colon Cancer; Recurrent Rectal Cancer; Stage IVA Colon Cancer; Stage IVA Rectal Cancer; Stage IVB Colon Cancer; Stage IVB Rectal Cancer

Interventions

irinotecan hydrochloride; leucovorin calcium; fluorouracil; cetuximab; bevacizumab

Participants

72

Sites

382

Countries

United States

Trials that died the same way

• Anti-gp100 Cells Plus ALVAC gp100 Vaccine to Treat Advanced Melanoma
  “The study was terminated due to low accrual.” (85% match in meaning)
• Pembrolizumab + Idelalisib for Lung Cancer Study
  “The study was terminated due to poor accrual.” (83% match in meaning)
• Bevacizumab (Avastin) in Unresectable/Recurrent Hemangioblastoma From Von-Hippel-Lindau Disease
  “Study terminated due to low accrual.” (83% match in meaning)
• Erwinase for Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) (IND 104224)
  “Study was terminated due to lack of accrual.” (83% match in meaning)
• Prevention of NAFLD in Hispanic Children
  “Study was terminated due to a lack of funding. Data collection was completed for 12-month outcomes; however, funding limitations prevented follow-up for longer timeframes, and some outcomes were not fully collected.” (82% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.