Autopsy report · NCT00343096

Randomized Trial Comparing 3 Routes of Delivering Lorazepam to Children.

“The buccal arm of the study was 30% less effective in stopping seizures within 10 minutes compared with the IV dose. This met a stopping rule for the study”

The sponsor’s own words in the registry.

Life of this trial

• Ran for about 2 years 9 months before it stopped.
• 800 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

Kamuzu University of Health Sciences

Sponsor type

University, hospital or other

Conditions

Status Epilepticus; Convulsions

Interventions

Lorazepam

Participants

800

Sites

1

Countries

Malawi

Trials that died the same way

• A Study to Test the Cardiac Effects of Padsevonil in Healthy Study Participants
  “Based on available data, UCB has decided to stop development of padsevonil as adjunctive treatment of focal-onset seizures” (56% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.