Autopsy report · NCT00139074

Seroquel in Acute Mania: Study to Investigate if Valproate Add-On Therapy is Superior to Quetiapine Monotherapy in Acutely Manic Patients

“terminated due to very low recruitment rate (27 June 2006)”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 month after it had already started.
• Ran for about 11 months before it stopped.
• 17 participants enrolled.
• No results are posted on the registry.

Vital statistics

Status

Terminated

Phase

Phase 4

Sponsor

AstraZeneca

Sponsor type

Industry

Conditions

Bipolar Disorder

Interventions

Quetiapine fumarate; sodium valproate

Participants

17

Sites

7

Countries

Denmark

Trials that died the same way

• Study of Nitazoxanide Tablets in the Treatment of Mild to Moderate Active Crohn's Disease
  “terminated due to slow recruitment” (85% match in meaning)
• Management of Platelet Transfusion Therapy in Patients With Blood Cancer or Treatment-Induced Thrombocytopenia
  “Terminated because of slow recruitment and lack of funding support” (84% match in meaning)
• Cromoglicate in Mastocytosis
  “prematurely terminated because of low recruitment” (83% match in meaning)
• Prontosan Quality of Life Study in Patients With Chronic Leg Wound(s)
  “Terminated due to prolonged subject recruitment” (81% match in meaning)
• Phase I Safety and Tolerability Study of Staphylococcal Protein A in Adult Patients With Chronic ITP
  “Terminated due to recruitment not meeting expectations.” (80% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.