Autopsy report · NCT00122980

Stroke With Transfusions Changing to Hydroxyurea

“The study has been stopped due to safety and futility concerns.”

The sponsor’s own words in the registry.

Life of this trial

• Registered 1 year 3 months before it started.
• Ran for about 4 years 2 months before it stopped.
• 134 participants enrolled.
• Results were posted on the registry 1 year 8 months after it ended.

Vital statistics

Status

Terminated

Phase

Phase 3

Sponsor

St. Jude Children's Research Hospital

Sponsor type

University, hospital or other

Conditions

Hemochromatosis; Cerebrovascular Accident; Anemia, Sickle Cell; Hematologic Diseases

Interventions

Red Cell Transfusions; Iron Chelation; Hydroxyurea; Phlebotomy

Participants

134

Sites

28

Countries

United States

Trials that died the same way

• Dose-finding Study of GSK2248761 in Antiretroviral Therapy-experienced Subjects With NNRTI-resistant HIV Infection
  “The study was stopped due to safety concerns” (88% match in meaning)
• Nasal High-frequency Jet Ventilation (nHFJV) Following Extubation in Preterm Infants
  “Study stopped due to safety reasons.” (83% match in meaning)
• An Efficacy and Safety Study of JNJ-26113100 in the Treatment of Adult Atopic Dermatitis
  “The study was stopped due to a non-clinical safety finding.” (82% match in meaning)
• Pembrolizumab (MK-3475) Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630)
  “The study stopped due to futility” (81% match in meaning)
• A Study of Idasanutlin With Cytarabine Versus Cytarabine Plus Placebo in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML)
  “The study was stopped for futility based on efficacy results at the interim analysis; no unexpected safety findings were observed.” (80% match in meaning)

Look deeper

• The official registry record (the source of truth)
• Record history: every change the sponsor made
• Open it in the database

Everything here comes from the current ClinicalTrials.gov record. The timeline uses the record’s dates; dates marked planned are the sponsor’s plans. The cause of death is an automatic, unverified label. This is research information, not medical advice.