M.D. Anderson Cancer Center

Why trials sponsored by M.D. Anderson Cancer Center stopped, in this sample of ClinicalTrials.gov.

76 stopped trials with a clear reason; 92% ended for non-scientific reasons.

Reason	Trials	Share
slow accrual	54	71%
funding business	9	12%
logistics pi	4	5%
futility	3	4%
manufacturing supply	2	3%
safety	2	3%
other	1	1%
regulatory	1	1%

Where it ranks

#4 of 90 sponsors by share of trials stopped for: slow accrual (71%).

Among ranked sponsors in this sample. Shares of stopped trials, not failure rates. See all scorecards.

Trials

A Trial of Regorafenib Plus Lorigerlimab in Patients With Locally Recurrent or Regrowing pMMR/MSS Localized Rectal Cancer
NCT07223567 · WITHDRAWN · slow accrual
“0 participants enrolled”
AIM4 AI and Mechanistic Modeling in Molecular Medicine
NCT06535828 · WITHDRAWN · slow accrual
“Withdrawn No Participants Enrolled”
A Phase II Study of Rivoceranib for Patients With Recurrent or Metastatic Olfactory Neuroblastoma
NCT06308575 · WITHDRAWN · slow accrual
“PI Request--No Patient Accrual”
A Phase 2 Study of INCB57643 (BET Inhibitor) in Combination With Ruxolitinib in JAK Inhibitor-naïve Patients With Myelofibrosis
NCT06619522 · WITHDRAWN · slow accrual
“0 participant accrual”
Phase Ib Trial of the KRAS G12C Inhibitor Adagrasib (MRTX849) in Combination With the PARP Inhibitor Olaparib in Patients With KRAS G12C Mutated Advanced Solid Tumors, With a Focus on Gynecological, Breast, Pancreatic and KEAP1 Mutated Non-small Cell Lung Cancers
NCT06130254 · TERMINATED · funding business
“Sponsor discontinued the trial”
18F-FSPG PET/CT as a Non-Invasive Imaging Biomarker for Treatment Response to Chemoradiation in Esophageal Cancer
NCT06549413 · TERMINATED · slow accrual
“\<75% participation”
Implementation of Digital Vital Sign Monitoring to Decrease Sleep Interruption and Enhance Recovery in Phase II of the PROmoting Sleep, Patient Engagement and Recovery (PROSPER) Project
NCT05456360 · TERMINATED · slow accrual
“Poor accrual and poor patient engagement with survey completion”
Study Assessing the Feasibility, Safety and Efficacy of Genetically Engineered Glucocorticoid Receptor Knock Out Virus Specific CTL Lines for Viral Infections in Immunosuppressed Cancer Patients
NCT05101213 · TERMINATED · slow accrual
“\<75% participation”
Pirtobrutinib (LOXO-305) Consolidation for MRD Eradication in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL) Treated With Venetoclax
NCT05317936 · TERMINATED · slow accrual
“\<75% participation”
Panitumumab and Pembrolizumab in Combination With Neoadjuvant Chemotherapy for the Treatment of Stage III-IV Triple Negative Breast Cancer
NCT05177796 · WITHDRAWN · slow accrual
“0 participants recruited”
Magnetic Particle-ICG Lymph Node Mapping in Colorectal Cancer
NCT05092750 · WITHDRAWN · slow accrual
“0 accrual”
Sintilimab for the Treatment of Locally Advanced, Metastatic, Recurrent, or Unresectable Undifferentiated Pleomorphic Sarcoma, SiARa Cancer Study
NCT05017103 · TERMINATED · funding business
“The drug sponsor stopped supporting study.”
Immunotherapy (NHS-IL12 & Bintrafusp Alfa) and Radiation Therapy for the Treatment of Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer, the REINA Trial
NCT04756505 · WITHDRAWN · funding business
“Per Sponsor Request-no longer manufacturing the study drug”
An Exercise and Nutrition Monitoring Intervention (Pt Pal) for the Improvement of Strength in Patients With Pancreatic or Stomach Cancer Receiving Chemoradiation Therapy Before Surgery, SurgeryStrong Study
NCT05056805 · WITHDRAWN · slow accrual
“No participants enrolled.”
Retifanlimab (INCMGA00012) and Telotristat Ethyl for the Treatment of Advanced Neuroendocrine Tumors and Carcinoid Syndrome
NCT04776876 · WITHDRAWN · funding business
“The study will not be opening. Support was withdrawn.”
Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer
NCT04521946 · WITHDRAWN · slow accrual
“No participants enrolled.”
Nab-paclitaxel and Alpelisib for the Treatment of Anthracycline Refractory Triple Negative Breast Cancer With PIK3CA or PTEN Alterations
NCT04216472 · TERMINATED · slow accrual
“\<75% participation”
Inotuzumab Ozogamicin and Chemotherapy in Treating Patients With Leukemia or Lymphoma Undergoing Stem Cell Transplantation
NCT03856216 · TERMINATED · slow accrual
“\<75% participation”
Transcranial Direct Current Stimulation in Reducing Pain in Cancer Patients With Chemotherapy Induced Peripheral Neuropathy
NCT04135326 · WITHDRAWN · slow accrual
“Per PI termination request, no patients enrolled”
Hyperpolarized Carbon C 13 Pyruvate Magnetic Resonance Spectroscopic Imaging in Predicting Treatment Response in Patients With Prostate Cancer
NCT03581500 · WITHDRAWN · slow accrual
“Committee could not find that the regulatory approval are met to re-approve this study.”
ADCT-602 in Treating Patients With Recurrent or Refractory B-cell Acute Lymphoblastic Leukemia
NCT03698552 · TERMINATED · slow accrual
“\<75% participation”
Rectal Administration of Opioids Using the Macy Catheter in Reducing Pain in Patients With Advanced Cancer
NCT03592459 · WITHDRAWN · other
“Study halted prematurely, prior to enrollment of first participant”
Phase II Trial of Nivolumab Plus Ipilimumab in Patients With Renal Medullary Carcinoma
NCT03274258 · TERMINATED · futility
“The study met its prespecified futility criteria during the prespecified interim futility analysis after enrolling the first cohort of 10 patients.”
Phase II Study of Fludarabine, Cytarabine (ARA-C) and Erwinase IV in Patients With Relapsed or Refractory Hematologic Malignancies
NCT02718755 · WITHDRAWN · manufacturing supply
“Problem with drug supply”
Utomilumab and ISA101b Vaccination in Patients With HPV-16-Positive Incurable Oropharyngeal Cancer
NCT03258008 · TERMINATED · slow accrual
“Closed the trial for infeasibility due to slow accrual”
Apalutamide, Abiraterone Acetate, and Prednisone in Treating Participants With Metastatic Castration Resistant Prostate Cancer
NCT03360721 · TERMINATED · slow accrual
“\<75% participation”
Dose Escalation and Cohort Expansion of Safety and Tolerability Study of Intratumoral rAd.CD40L (ISF35) in Combination of Systemic Pembrolizumab in Patients With Refractory Metastatic Melanoma
NCT02719015 · WITHDRAWN · regulatory
“No IND Serial #”
Venetoclax and Decitabine in Treating Participants With Relapsed/Refractory Acute Myeloid Leukemia or Relapsed High-Risk Myelodysplastic Syndrome
NCT03404193 · TERMINATED · slow accrual
“\<75% participation”
Study of Adoptive Cellular Therapy Using Autologous T Cells Transduced With Lentivirus to Express a CD33 Specific Chimeric Antigen Receptor in Patients With Relapsed or Refractory CD33-Positive Acute Myeloid Leukemia
NCT03126864 · TERMINATED · logistics pi
“Terminated per the PI's request.”
Phase II Study of Ilorasertib (ABT348) in Patients With CDKN2A Deficient Solid Tumors
NCT02478320 · TERMINATED · funding business
“Study terminated due to company's decision to discontinue drug development”
Telemonitoring After Surgery to Preserve Limb Function in Optimizing Mobility in Cancer Survivors With Skeletal Metastases
NCT02715856 · TERMINATED · funding business
“Due to software issues and depletion of funds the protocol was terminated early”
Study of Loratadine for Pegfilgrastim Induced Bone Pain in Patients With Aggressive Lymphoma
NCT02392039 · TERMINATED · slow accrual
“Slow Accrual”
Metformin for Reduction of Paclitaxel-Related Neuropathy in Patients With Breast Cancer
NCT02360059 · TERMINATED · slow accrual
“Low Accrual”
Nintedanib For HER2-Negative Metastatic Inflammatory Breast Cancer (MIBC)
NCT02389764 · TERMINATED · slow accrual
“Slow Accrual”
Lirilumab and Azacitidine in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia
NCT02399917 · TERMINATED · slow accrual
“This study was terminated early due to response rates not meeting the anticipated minimum of 30%.”
An Open-Label, Phase I/II Study of Nilotinib (Tasigna) and MEK-162 (ARRY-162) Used in Combination for Patients With Refractory or Advanced Chronic Myeloid Leukemia and Philadelphia Positive Acute Leukemia (Protocol CAMN107AUS41T)
NCT02225574 · TERMINATED · slow accrual
“Slow Accrual - Only 1 patient enrolled in Phase 1 - Study never went to Phase II”
Pomalidomide, Dexamethasone, and Filgrastim-sndz in Treating Patients With Relapsed or Refractory Multiple Myeloma
NCT01946152 · TERMINATED · logistics pi
“Per PI at time of CR”
Telaprevir Plus Standard of Care (SOC) in HCV Associated Hepatocellular Carcinoma (HCC)
NCT01821963 · TERMINATED · slow accrual
“Low referral rate due to new therapeutic options.”
Stereotactic Body Radiotherapy (SBRT) Versus Stereotactic Body Proton Therapy (SBPT)
NCT01511081 · TERMINATED · slow accrual
“Low Accrual”
Cryoablation for Invasive Breast Carcinoma Following Neoadjuvant Therapy
NCT01388777 · TERMINATED · slow accrual
“Early termination leading to small number of subjects analyzed”
Fish Oil Versus Statins Versus Placebos in Reducing Atrial Fibrillation in Patients Undergoing Thoracic Surgery for Lung Cancer
NCT01259284 · TERMINATED · slow accrual
“Terminated due to low accrual.”
Pomalidomide in Treating Patients With Relapsed or Refractory Waldenstrom Macroglobulinemia
NCT01198067 · TERMINATED · slow accrual
“\<75% participant accrual”
Outpatient Neutropenic Diet Study
NCT00947648 · TERMINATED · slow accrual
“Slow Accrual”
Breast Magnetic Resonance Imaging (MRI) Screening After Mantle Radiation Therapy
NCT00925405 · TERMINATED · slow accrual
“Low accrual”
Oral Clofarabine in Chronic Lymphocytic Leukemia (CLL)
NCT00800566 · WITHDRAWN · funding business
“Sponsor terminated.”
Preoperative Chemotherapy (Gemcitabine and Erlotinib) With or Without Radiation Therapy
NCT00766636 · TERMINATED · slow accrual
“Slow Accrual”
Irinotecan Plus Lenalidomide in Adult Patients With Recurrent Glioblastoma Multiforme: Phase I
NCT00671801 · TERMINATED · safety
“Toxicity”
Long Term Minor Sibling Donor Well-Being
NCT00667784 · TERMINATED · slow accrual
“Slow accrual.”
Carotid Artery Disease in Childhood Cancer Survivors
NCT00591539 · TERMINATED · slow accrual
“Slow Accrual.”
Autologous Stem Cell Rescue With CD133+ Selected Cells in High-Risk Neuroblastoma
NCT00539500 · TERMINATED · slow accrual
“Slow Accrual.”
Cardiac Biomarkers in Early Detection of Cardiotoxicity in Patients Receiving Sunitinib or Sorafenib Chemotherapy
NCT00532064 · TERMINATED · logistics pi
“Terminated per PI's request”
ZD6474 Alone and in Combination With Retinoic Acid in Pediatric Neuroblastoma
NCT00533169 · TERMINATED · slow accrual
“Lack of enrollment.”
Thermal Signature of Patients Undergoing Radiation Therapy
NCT00508313 · WITHDRAWN · slow accrual
“Study closed early without enrollment.”
Feasibility Study of Acute Myelogenous Leukemia mRNA Plus Lysate Loaded Dendritic Cell Vaccines
NCT00514189 · TERMINATED · slow accrual
“Terminated early due to slow accrual.”
Proton Therapy With Capecitabine for Rectal Cancer
NCT00503932 · WITHDRAWN · slow accrual
“No participant enrollment.”
Oxaliplatin, Fludarabine, and Cytarabine in Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndromes (MDS)
NCT00480987 · TERMINATED · funding business
“Lack of support.”
Urodynamic Evaluation in Post-radiation Salvage Prostatectomy Patients
NCT00901420 · TERMINATED · slow accrual
“Terminated due to slow accrual.”
Biochemotherapy With Temozolomide for Metastatic Melanoma
NCT00505635 · TERMINATED · slow accrual
“Slow accrual”
Amifostine With IMRT for Submandibular and Sublingual Salivary Sparing During Head and Neck Cancer Treatment
NCT00409331 · TERMINATED · logistics pi
“Study terminated by Principal Investigator; no patients completed study.”
Phase I-II for Patients With Recurrent or Refractory Non-small Cell Lung Cancer (NSCLC)
NCT00411593 · WITHDRAWN · slow accrual
“Lack of Patient Accrual”
Quality of Life in Men With High Risk Localized Prostate Cancer
NCT00877617 · WITHDRAWN · slow accrual
“Slow accrual”
Collection of Outcomes Data for Pregnant Patients With Cancer
NCT00507572 · TERMINATED · slow accrual
“\<75% participation”
RAD001 Plus Docetaxel in Patients With Metastatic Breast Cancer
NCT00253318 · TERMINATED · safety
“Toxicity and Lack of Efficacy”
Folfox-B Study for Patients With Colorectal Liver Metastases
NCT00508872 · TERMINATED · slow accrual
“Slow accrual, study terminated.”
Fatigue in Emergency Center Patients
NCT00504985 · TERMINATED · slow accrual
“Low Accrual”
Quantitation of Left Ventricular Ejection Fraction as Part of F-18 FDG Whole Body PET/CT Scans For Tumor Staging
NCT00499382 · TERMINATED · slow accrual
“Slow accrual; study terminated.”
Effect of Tight Control of Blood Glucose During Hyper-CVAD Chemotherapy For Acute Lymphocytic Leukemia (ALL)
NCT00500240 · TERMINATED · futility
“Terminated early due to futility.”
Natrecor in Pulmonary Hypertension
NCT00075179 · TERMINATED · slow accrual
“Low accrual.”
Rituximab Maintenance After Autologous Transplantation
NCT01103388 · TERMINATED · slow accrual
“Closed early due to slow patient accrual and sponsor's withdrawal of support.”
Comparison of Sulindac, Aspirin, and Ursodiol in Preventing Colorectal Cancer
NCT00062023 · TERMINATED · funding business
“Study closed by the NCI.”
Autologous and Allogenic Transplantation With Campath-1H for T-Cell Lymphoma
NCT00505921 · TERMINATED · slow accrual
“Slow Accrual.”
Prevalence of Secondary Hypogonadism in Male Patients on Chronic Opioid Therapy for Cancer-Related Pain Syndromes
NCT00529230 · TERMINATED · slow accrual
“Low accrual rate.”
Study of Vioxx and Radiation Therapy for Brainstem Glioma
NCT00038389 · TERMINATED · manufacturing supply
“Unavailability of study drug.”
Bortezomib in Treating Patients With Chronic Myelogenous Leukemia
NCT00023881 · TERMINATED · futility
“Lack of efficacy”
SCH 66336 Before Surgery in Treating Patients With Colorectal Cancer That Has Metastasized to the Liver
NCT00005030 · WITHDRAWN · slow accrual
“No enrollment.”
Study of Gemcitabine Chemoradiation and TNP-470 Patients Locally Advanced, Nonmetastatic Adenocarcinoma of Pancreas
NCT00038701 · TERMINATED · slow accrual
“Slow accrual.”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.