Duke University

Why trials sponsored by Duke University stopped, in this sample of ClinicalTrials.gov.

54 stopped trials with a clear reason; 94% ended for non-scientific reasons.

Trials

• Coping With Asthma Throughout Life Management Program
  NCT07044388 · WITHDRAWN · logistics pi
  “PI departure from institution”
• Proprio Spine Measurement Tool
  NCT07023393 · WITHDRAWN · funding business
  “Budgeting Concerns”
• Time Restricted Eating (TRE) in Metastatic Head and Neck Squamous Cell Cancer (mHNSCC) or Unresectable or Metastatic Renal Cell Carcinoma (RCC)
  NCT06603155 · WITHDRAWN · funding business
  “Changing priorities of portfolio”
• Pain Profile and Pain Medication Use After THA and TKA
  NCT03714711 · WITHDRAWN · funding business
  “PI decided to close due to current funding and future funding constraints on internal studies.”
• IIT PH1 KDS-1001 in Patients With CML
  NCT04808115 · WITHDRAWN · other
  “Study halted prematurely, prior to enrollment of first participant.”
• GRETeL: Tumor Response to Standard Radiotherapy and TMZ Patients With GBM
  NCT05695976 · SUSPENDED · other
  “The study is suspended while preplanned interim analysis is being completed.”
• Hearts of Athletes
  NCT04736004 · TERMINATED · slow accrual
  “Study terminated due to insufficient participant enrollment during the COVID-19 pandemic, which impacted recruitment timelines and feasibility of meeting study objectives.”
• Data-driven Approaches to Healthcare Provider Resilience & Burnout During COVID-19
  NCT04922632 · TERMINATED · funding business
  “Funding was exhausted”
• VAC Bioburden Wound Care Assessment
  NCT04826965 · TERMINATED · slow accrual
  “Slow accrual”
• AirFLO2 Treatment for Hypoxia and/or Tachypnea in Patients With COVID-19
  NCT04649775 · TERMINATED · slow accrual
  “no eligible participants”
• Glucagon Receptor Inhibition to Enable Breast Cancer Patients to Benefit From PI3K Inhibitor Therapy (REMD-477)
  NCT04330625 · TERMINATED · slow accrual
  “Lack of enrollment”
• Immediate Prostatectomy vs. Cabozantinib Followed by Prostatectomy in Men With High-Risk Prostate Cancer
  NCT03964337 · TERMINATED · slow accrual
  “Poor accrual.”
• Measuring Evoked Potentials From the Spinal Cord and Dorsal Root Ganglion
  NCT03976219 · TERMINATED · funding business
  “Budgetary Issues”
• Cancer Treatment Decision-making in the HIV Population: an Observational Study of Physician-patient Interactions
  NCT03721796 · TERMINATED · logistics pi
  “study design changed due to COVID-19”
• iControl Chronic Kidney Disease
  NCT03951363 · TERMINATED · logistics pi
  “Terminated due to COVID-19”
• ACDF Comparison Trial
  NCT03187171 · WITHDRAWN · funding business
  “Funding”
• A Prospective Study of LessRay Enhanced Versus Standard Fluoroscopic Visualization in Surgical Placement of Spinal Cord Stimulator
  NCT02827539 · WITHDRAWN · logistics pi
  “Change in resources to support study activities”
• Reach Home and Read
  NCT03699592 · TERMINATED · slow accrual
  “Low enrollment.”
• Aviation Portable Oxygen Delivery System
  NCT03425409 · WITHDRAWN · funding business
  “Sponsor decision”
• Polypharmacy-related Adverse Events in Critically Ill Children
  NCT03293927 · WITHDRAWN · slow accrual
  “No participants enrolled in study.”
• Role of Virtual Reality (VR) in Patients With Sickle Cell Disease (SCD)
  NCT03387033 · TERMINATED · funding business
  “enrollment closed due to lack of funding”
• Fulfillment of Expectations for Patients With FAI Syndrome
  NCT03278353 · TERMINATED · slow accrual
  “Lack of enrollment”
• Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU
  NCT02903407 · TERMINATED · slow accrual
  “All enrolled participants completed the study protocol but the study was terminated prior to the goal number of participants due to low recruitment”
• Quality of Life Following ECMO
  NCT02809703 · WITHDRAWN · logistics pi
  “PI departed study site. Study closed.”
• Mirvetuximab Soravtansine (IMG853) in Folate Receptor Alpha-expressing TNBC
  NCT03045393 · WITHDRAWN · slow accrual
  “Inadequate enrollment”
• The Anatomic Determinants of Perforation Induced Hearing Loss
  NCT03271970 · WITHDRAWN · logistics pi
  “PI no longer wishes to conduct the study. No participants were enrolled.”
• The Relationship Between GOLD Risk Group and Clinical Outcomes in a Community-based COPD Cohort
  NCT02838108 · TERMINATED · funding business
  “Sponsor Decision to Stop Recruitment”
• Safety of Anti-Depressant for Chronic Obstructive Pulmonary Disease (SAD-COPD)
  NCT02813447 · TERMINATED · logistics pi
  “COVID-19 hold”
• Effects of E-cigarettes (ECIGs) on Pulmonary Inflammation and Behavior in HIV Infected Smokers
  NCT02848586 · TERMINATED · slow accrual
  “Recruitment failed due to lack of subjects meeting the eligibility criteria”
• Effectiveness of ROTEM-based Coagulation Surveillance on Reducing Blood Product Utilization During Complex Spine Surgery
  NCT02758184 · TERMINATED · slow accrual
  “Slow enrollment”
• Left Bundle Branch Block ECG Characteristics in the Evaluation of Acute Coronary Syndrome
  NCT02283619 · TERMINATED · slow accrual
  “Study was found to be non-feasible. Not enough patients to perform an adequate study in the allocated time period.”
• School Reintegration After Pediatric Hematopoietic Stem Cell Transplant
  NCT02052570 · WITHDRAWN · slow accrual
  “Unable to meet all criteria as outlined for participants”
• ACE-Inhibitor Effects on Total Hip and Knee Arthroplasty Patients
  NCT01867047 · TERMINATED · other
  “Following an interim analysis the study team felt that there was enough data that showed no significant difference.”
• Clinical Evaluation of Direct Dorsal Column Stimulation
  NCT02020460 · TERMINATED · slow accrual
  “low accrual”
• Pre and or Post Operative Blood Pressure Control With Clevidipine (Cleviprexm Medicines Company) in Aortic Aneurysm / Dissection
  NCT01480531 · WITHDRAWN · slow accrual
  “We elected to stop this study due to our inability to recruit suitable subjects.”
• Right Ventricular (RV) Pacing in Early Post-operative Continuous Flow Left Ventricular Assist Device (LVAD)
  NCT01446796 · TERMINATED · slow accrual
  “Recruitment futility”
• Study Of Abraxane® And Carboplatin As First-Line Treatment For Triple Negative Metastatic Breast Cancer
  NCT01207102 · TERMINATED · slow accrual
  “Low enrollment and there is insufficient data to publish.”
• Effects of Metformin and Fish Oil on Treatment With Clozapine
  NCT02140788 · TERMINATED · logistics pi
  “PI left institution”
• Statin Therapy To Limit Cognitive Dysfunction After Cardiac Surgery
  NCT01186289 · WITHDRAWN · funding business
  “Principal Investigator decided not to pursue enrollment due to changes in standard of care.”
• Local Modulation of Immune Receptors to Enhance the Response to Dendritic Cell Vaccination in Metastatic Melanoma
  NCT01216436 · TERMINATED · logistics pi
  “The PI retired”
• Genomic Guided Therapy With Dasatinib or Nilutamide in Metastatic Castration-Resistant Prostate Cancer
  NCT00918385 · TERMINATED · funding business
  “Permanent closure of trial to further accrual based on IDE disapproval”
• Stereotactic Radiosurgery in Treating Patients With Brain Metastases
  NCT00811655 · TERMINATED · slow accrual
  “Slow recruitment”
• Phase II Study of Dasatinib in Previously Treated Patients With Advanced NSCLC
  NCT00787267 · TERMINATED · slow accrual
  “Poor accrual”
• Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure
  NCT00608140 · TERMINATED · slow accrual
  “Unable to recruit sufficient numbers of patients.”
• Pharmacokinetic Study of Fondaparinux in Outpatients With Renal Dysfunction
  NCT00483600 · WITHDRAWN · slow accrual
  “unable to enroll”
• A Phase II Safety and Tolerability Study of Bevacizumab When Added to Single-agent Chemotherapy to Treat Patient With Breast Cancer Metastatic to Brain
  NCT00476827 · TERMINATED · slow accrual
  “Slow accrual”
• A Phase I/Expansion Study of Dasatinib
  NCT00598091 · TERMINATED · slow accrual
  “Low accrual, unable to meet endpoint in timely manner”
• Bortezomib (Velcade) With Standard Chemotherapy for Relapsed or Refractory Follicular Lymphoma
  NCT00510887 · TERMINATED · slow accrual
  “Low accrual.”
• Dose-Dense Induction/Neoadjuvant Chemotherapy in Locally Advanced Non-Small Cell Lung Cancer
  NCT02157116 · TERMINATED · slow accrual
  “Insufficient accrual to meet analysis goals”
• Augmentation Study of Levetiracetam in Obsessive Compulsive Disorder
  NCT00299611 · TERMINATED · funding business
  “Sponsor decided to terminate the study due to budget consideration”
• Maximum Tolerated Dose, Safety and Efficacy of Docetaxel / Cisplatin + STI571
  NCT02127372 · TERMINATED · slow accrual
  “The study was closed due to poor accrual”
• Testing Pharmacological Therapies for Pregnant Smokers
  NCT00224419 · TERMINATED · funding business
  “was terminated due to meeting a priori stopping rule set by DSMB”
• Nonmyeloablative Allo Stem Cell Transplant for Severe Autoimmune Diseases
  NCT00849745 · TERMINATED · slow accrual
  “low accrual”
• Use of a Perineometer to Assess Pelvic Muscle Tone
  NCT02345538 · WITHDRAWN · slow accrual
  “Investigator did not start the project in time; study team decided it was not feasible to begin study as resident was soon graduating. No patients enrolled.”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.