:root{--bg:#F6F4EF;--ink:#1F1D1A;--muted:#6F6B63;--line:#DAD6CC;--chip:#E9E5DA;--navbg:rgba(246,244,239,.86);
--band:#1F1D1A;--bandink:#F6F4EF;--bandmuted:#A8A399;
--sans:-apple-system,"Segoe UI",Inter,Helvetica,Arial,sans-serif;
--serif:"Iowan Old Style","Palatino Linotype",Palatino,Georgia,"Times New Roman",serif}
@media (prefers-color-scheme:dark){:root{--bg:#1F1D1A;--ink:#F2F0EA;--muted:#A39F95;--line:#3B3833;--chip:#2E2B27;--navbg:rgba(31,29,26,.86);--band:#141311}}
*{box-sizing:border-box}
body{margin:0;background:var(--bg);color:var(--ink);font:16px/1.5 var(--sans);-webkit-font-smoothing:antialiased}
a{color:inherit;text-underline-offset:3px}
.wrap{max-width:1180px;margin:0 auto;padding:0 28px}
.top{position:sticky;top:0;z-index:5;background:var(--navbg);backdrop-filter:blur(12px);-webkit-backdrop-filter:blur(12px);border-bottom:1px solid var(--line)}
.top .wrap{display:flex;align-items:center;justify-content:space-between;height:60px;gap:16px}
.brand{font:500 1.35rem var(--serif);letter-spacing:-.01em}
.credit{font-size:.82rem;color:var(--muted);text-align:right}
.hero{display:grid;gap:28px;padding-top:72px;padding-bottom:40px}
h1{font:500 clamp(2.4rem,6vw,4rem)/1.04 var(--serif);letter-spacing:-.02em;margin:0}
.lede{font-size:1.15rem;color:var(--muted);margin:0 0 14px;max-width:46ch}
.note{border-top:1px solid var(--line);border-bottom:1px solid var(--line);padding:12px 0;font-size:.9rem;color:var(--muted)}
.note strong{color:var(--ink)}
@media (min-width:820px){.hero{grid-template-columns:1.1fr 1fr;align-items:end}}
.band{background:var(--band);color:var(--bandink);padding:52px 0 56px;margin-top:24px}
.band h2{font:500 clamp(1.6rem,3vw,2.1rem)/1.15 var(--serif);margin:0 0 28px}
.stats{display:grid;grid-template-columns:repeat(2,1fr);gap:20px 24px}
@media (min-width:820px){.stats{grid-template-columns:repeat(5,1fr)}}
.stat{all:unset;box-sizing:border-box;cursor:pointer;padding:14px 0;border-top:2px solid var(--bandink);display:block}
.stat:hover .n{opacity:.7}
.stat:focus-visible{outline:2px solid var(--bandink);outline-offset:2px}
.stat .n{display:block;font:500 2.3rem/1.1 var(--serif)}
.stat .l{display:block;font-size:.78rem;text-transform:uppercase;letter-spacing:.06em;color:var(--bandmuted);margin-top:4px}
.search{padding-top:40px;padding-bottom:8px}
.controls{display:grid;gap:12px;grid-template-columns:1fr}
@media (min-width:820px){.controls{grid-template-columns:2fr 1fr}}
input[type=search],input[type=email],select{height:46px;padding:0 14px;font:inherit;color:var(--ink);background:transparent;border:1px solid var(--line);border-radius:2px;width:100%}
input[type=search]:focus,input[type=email]:focus,select:focus{outline:2px solid var(--ink);outline-offset:-1px}
.checks{display:flex;flex-wrap:wrap;gap:8px 26px;font-size:.92rem;margin-top:14px}
.checks label{display:flex;align-items:center;gap:8px;cursor:pointer}
#count{color:var(--muted);font-size:.9rem;margin:18px 0 6px}
.row{display:grid;gap:8px 28px;padding:22px 0;border-top:1px solid var(--line)}
@media (min-width:820px){.row{grid-template-columns:220px 1fr}}
.side{font-size:.88rem;color:var(--muted)}
.side .id{display:block;color:var(--ink);font-weight:500;margin-bottom:2px}
.row h3{font:500 1.3rem/1.25 var(--serif);margin:0 0 10px}
.why{margin:0 0 10px}
.meta{color:var(--muted);font-size:.85rem}
.badge{display:inline-block;padding:3px 8px;border-radius:2px;background:var(--chip);font-size:.7rem;text-transform:uppercase;letter-spacing:.07em;font-weight:500;margin:0 6px 6px 0}
.badge.ns{background:var(--ink);color:var(--bg)}
.badge.low{background:transparent;border:1px dashed var(--muted);color:var(--muted)}
.btn{height:46px;padding:0 22px;font:500 .95rem var(--sans);color:var(--bg);background:var(--ink);border:0;border-radius:2px;cursor:pointer}
.btn:hover{opacity:.85}
.more{padding:20px 0 48px;border-top:1px solid var(--line)}
.tools{display:flex;flex-wrap:wrap;align-items:center;justify-content:space-between;gap:12px}
.btn.ghost{background:transparent;color:var(--ink);border:1px solid var(--ink)}
.btn.ghost:hover{background:var(--ink);color:var(--bg);opacity:1}
.signup{padding-top:44px;padding-bottom:48px;border-top:1px solid var(--line)}
.signup h2{font:500 clamp(1.5rem,3vw,2rem)/1.15 var(--serif);margin:0 0 8px}
.consent{display:flex;gap:8px;align-items:flex-start;font-size:.88rem;color:var(--muted);margin:12px 0 16px}
.hp{position:absolute;left:-9999px;height:0;overflow:hidden}
a.brand{text-decoration:none;color:var(--ink)}
.nav{color:var(--ink);margin-right:6px}
.page{padding-top:56px;padding-bottom:56px;max-width:760px}
.page h1{font:500 clamp(2rem,5vw,3rem)/1.1 var(--serif);margin:0 0 14px}
.page h2{font:500 1.35rem var(--serif);margin:28px 0 6px}
.page p,.page li{color:var(--muted)}
.offer-grid{display:grid;gap:16px;margin:28px 0}
@media (min-width:820px){.offer-grid{grid-template-columns:repeat(3,1fr)}}
.offer{border:1px solid var(--line);border-radius:2px;padding:20px;display:flex;flex-direction:column;gap:10px}
.offer h3{font:500 1.2rem/1.2 var(--serif);margin:0}
.offer .price{font:500 1.6rem var(--serif)}
.offer p{margin:0;font-size:.92rem;color:var(--muted);flex:1}
.offer a.btn{display:flex;align-items:center;justify-content:center;text-decoration:none}
footer a{margin-right:14px}
.page table{width:100%;border-collapse:collapse;margin:14px 0}
.page th,.page td{text-align:left;padding:8px 10px;border-bottom:1px solid var(--line);font-size:.92rem}
.page th{color:var(--ink);font-weight:500}
.page ul.plain{list-style:none;padding:0}
.page ul.plain li{padding:14px 0;border-top:1px solid var(--line)}
.page ul.cols{columns:2;column-gap:28px;padding-left:18px}
@media (max-width:640px){.page ul.cols{columns:1}}
.skip{position:absolute;left:-9999px;top:8px}
.gate{padding-top:24px;padding-bottom:72px;max-width:640px}
.gate h2{font:500 clamp(1.6rem,3vw,2.2rem)/1.15 var(--serif);margin:0 0 8px}
.gate .controls{margin-top:14px}
.gate .fine{font-size:.85rem;color:var(--muted)}
.btn.small{height:34px;padding:0 14px;font-size:.85rem}
.who{margin-right:10px;color:var(--muted)}
.notice{background:var(--chip);padding:10px 16px;font-size:.9rem;text-align:center}
.panel{border:1px solid var(--line);border-radius:2px;padding:12px 16px;margin-top:14px}
.panel summary{cursor:pointer;font-weight:500}
.panel p.meta{margin:8px 0}
.saved{list-style:none;padding:0;margin:10px 0}
.saved-item{display:flex;flex-wrap:wrap;align-items:center;gap:10px;padding:8px 0;border-top:1px solid var(--line)}
.saved-name{flex:1;min-width:140px}
.saved-item .badge{margin:0}
.saved-item .link-btn{margin:0}
.panel .filters{margin-top:10px}
input[type=text]{height:46px;padding:0 14px;font:inherit;color:var(--ink);background:transparent;border:1px solid var(--line);border-radius:2px;width:100%}
table.cmp{width:100%;border-collapse:collapse;margin-top:14px}
table.cmp th,table.cmp td{text-align:left;padding:8px 10px;border-bottom:1px solid var(--line);font-size:.9rem}
table.cmp meter{width:120px;height:10px;vertical-align:middle}
.pct{color:var(--muted);font-size:.85rem}
dialog input[type=email],dialog input[type=text]{margin-top:4px}
.skip:focus{left:8px;z-index:20;background:var(--bg);color:var(--ink);padding:8px 12px;border:2px solid var(--ink)}
#search:focus{outline:none}
.btn:focus-visible,.link-btn:focus-visible,select:focus-visible,a:focus-visible{outline:2px solid var(--ink);outline-offset:2px}
.filters{display:grid;gap:12px;grid-template-columns:1fr 1fr;margin-top:12px}
@media (min-width:820px){.filters{grid-template-columns:repeat(4,1fr)}}
.link-btn{all:unset;cursor:pointer;margin-top:8px;font-size:.82rem;color:var(--muted);text-decoration:underline;text-underline-offset:3px}
.link-btn:hover{color:var(--ink)}
dialog{border:1px solid var(--ink);border-radius:2px;background:var(--bg);color:var(--ink);padding:24px;max-width:460px;width:calc(100% - 32px)}
dialog::backdrop{background:rgba(0,0,0,.5)}
dialog h2{font:500 1.4rem var(--serif);margin:0 0 8px}
dialog label{display:block;margin:12px 0 4px;font-size:.9rem}
dialog select,dialog textarea{width:100%;font:inherit;color:var(--ink);background:transparent;border:1px solid var(--line);border-radius:2px;padding:10px}
dialog textarea{min-height:90px;resize:vertical}
.dlg-actions{display:flex;gap:10px;margin-top:16px}
.chart-title{font:500 1.15rem var(--serif);margin:36px 0 8px}
#chart svg{width:100%;height:auto;display:block}
.bar-ns{fill:var(--bandink)}
.bar-sci{fill:var(--bandmuted)}
.axis{fill:var(--bandmuted);font:11px var(--sans)}
.legend{display:flex;gap:18px;font-size:.82rem;color:var(--bandmuted);margin-top:8px}
.legend .sw{display:inline-block;width:10px;height:10px;margin-right:6px}
.legend .sw.ns{background:var(--bandink)}
.legend .sw.sci{background:var(--bandmuted)}
@media (prefers-reduced-motion:reduce){*{scroll-behavior:auto}}
footer{border-top:1px solid var(--line);padding:26px 0 40px;font-size:.85rem;color:var(--muted)}
.c-safety{background:#B8412F;fill:#B8412F}.c-futility{background:#7A6A9E;fill:#7A6A9E}.c-slow_accrual{background:#3E7C8C;fill:#3E7C8C}
.c-funding_business{background:#C58A2B;fill:#C58A2B}.c-manufacturing_supply{background:#6C8F4E;fill:#6C8F4E}.c-regulatory{background:#8C5A3C;fill:#8C5A3C}
.c-logistics_pi{background:#4F6FA8;fill:#4F6FA8}.c-other{background:#8A867D;fill:#8A867D}
.tabs{display:flex;gap:4px;border-bottom:1px solid var(--line);overflow-x:auto;margin-top:8px}
.tab{all:unset;box-sizing:border-box;cursor:pointer;padding:12px 16px;font-weight:500;white-space:nowrap;border-bottom:2px solid transparent;color:var(--muted)}
.tab[aria-selected=true]{color:var(--ink);border-bottom-color:var(--ink)}
.tab:focus-visible{outline:2px solid var(--ink);outline-offset:-2px}
.xpanel{padding-top:32px;padding-bottom:56px}
.dark-title{margin-top:32px}.dark-lede{max-width:60ch}
.trend-svg,.heat-svg{width:100%;height:auto;display:block}
.axis2{fill:var(--muted);font:11px var(--sans)}
.mark{stroke:var(--ink);stroke-dasharray:3 3;opacity:.5}.mark-text{fill:var(--ink);font:11px var(--sans)}
.heat-cell{fill:var(--ink)}.heat-label{fill:var(--ink);font:12px var(--sans)}
.heat-num{fill:var(--ink);stroke:var(--bg);stroke-width:3px;paint-order:stroke;font:11px var(--sans)}
.legend-row{display:flex;flex-wrap:wrap;gap:6px 16px;font-size:.82rem;color:var(--muted);margin:10px 0}
.legend-row .sw{display:inline-block;width:10px;height:10px;margin-right:6px}
ul.insights{color:var(--muted);padding-left:20px}
.game-bar{margin:10px 0 16px}
.game-card{border:1px solid var(--line);padding:22px;max-width:720px}
.game-card h3{font:500 1.35rem/1.25 var(--serif);margin:6px 0 10px}
.game-q{font-weight:500;margin:18px 0 8px}
.choices{display:grid;gap:10px;grid-template-columns:1fr}
@media (min-width:640px){.choices{grid-template-columns:1fr 1fr}}
.btn.choice{height:auto;min-height:46px;padding:10px 14px;text-align:left}
.game-card h3.right{color:#2E7D4F}.game-card h3.wrong{color:#B8412F}
.game-reason{font:italic 1.15rem/1.4 var(--serif);margin:12px 0}
.game-squares{font-size:1.7rem;letter-spacing:.12em;margin:8px 0}
.fame-hero{border:2px solid var(--ink);padding:26px;margin:18px 0}
.fame-quote{font:500 1.5rem/1.3 var(--serif);margin:10px 0}.fame-quote.small{font-size:1.1rem}
.fame-grid{display:grid;gap:16px;grid-template-columns:1fr}
@media (min-width:820px){.fame-grid{grid-template-columns:1fr 1fr}}
.fame-card{border:1px solid var(--line);padding:18px}
.fame-actions{display:flex;gap:14px;align-items:center}
.news-list{list-style:none;padding:0;margin:14px 0}.news-item{padding:14px 0;border-top:1px solid var(--line)}.news-title{font:500 1.1rem/1.3 var(--serif)}
.case-list{display:grid;grid-template-columns:max-content 1fr;gap:6px 14px;font-size:.9rem}.case-list dt{color:var(--muted)}.case-list dd{margin:0}
.case-sim{padding-left:18px;font-size:.88rem;color:var(--muted)}
dialog#case-dialog{max-width:640px;max-height:85vh;overflow:auto}
.explore{display:grid;gap:12px;grid-template-columns:1fr;padding-bottom:8px}
@media (min-width:640px){.explore{grid-template-columns:repeat(2,1fr)}}
@media (min-width:1000px){.explore{grid-template-columns:repeat(6,1fr)}}
.tile{display:flex;flex-direction:column;gap:4px;border:1px solid var(--line);padding:14px 16px;text-decoration:none}
.tile:hover{border-color:var(--ink)}.tile strong{font:500 1.05rem var(--serif)}.tile span{font-size:.82rem;color:var(--muted)}
.xscroll{overflow-x:auto;-webkit-overflow-scrolling:touch}
.xscroll>svg{min-width:640px}.xscroll>table{min-width:420px}
.mark-text{paint-order:stroke;stroke:var(--bg);stroke-width:3px}
@media (prefers-color-scheme:dark){.game-card h3.right{color:#5BC187}.game-card h3.wrong{color:#F08A78}}
.sqlbox{width:100%;min-height:160px;padding:12px;font:14px/1.45 ui-monospace,Menlo,Consolas,monospace;color:var(--ink);background:transparent;border:1px solid var(--line);border-radius:2px;resize:vertical}
.sqlbox:focus{outline:2px solid var(--ink);outline-offset:-1px}
.sql-examples{display:flex;flex-wrap:wrap;gap:8px;margin:10px 0}
.sql-out{overflow-x:auto;margin-top:12px}
.band-note{margin:22px 0 0;color:var(--bandmuted);max-width:70ch}.band-note:empty{display:none}.people-num{color:var(--bandink);font:500 1.6rem var(--serif)}
.link-btn.light{color:var(--bandink)}
.map-wrap{margin-top:14px;overflow-x:auto}.map-svg{width:100%;min-width:640px;height:auto;display:block}
.land{fill:var(--chip);stroke:var(--bg);stroke-width:.5}.land.on{fill:var(--ink)}.land.thin{fill:var(--line)}
.land.on.c-safety{fill:#B8412F}.land.on.c-futility{fill:#7A6A9E}.land.on.c-slow_accrual{fill:#3E7C8C}.land.on.c-funding_business{fill:#C58A2B}.land.on.c-manufacturing_supply{fill:#6C8F4E}.land.on.c-regulatory{fill:#8C5A3C}.land.on.c-logistics_pi{fill:#4F6FA8}.land.on.c-other{fill:#8A867D}
.land:hover{stroke:var(--ink);stroke-width:1}
.map-info{min-height:1.5em}.life-grid{display:grid;gap:16px;grid-template-columns:1fr;margin-top:14px}
@media (min-width:820px){.life-grid{grid-template-columns:1fr 1fr}}
.board-big{margin:16px 0}.board-num{font:500 clamp(2.6rem,8vw,5rem)/1 var(--serif)}
.kicker{font-size:.78rem;text-transform:uppercase;letter-spacing:.14em;color:var(--muted);margin:0 0 10px}
.page h1.trial-title{font-size:clamp(1.7rem,4vw,2.5rem)}
.verdict{display:flex;flex-direction:column;gap:4px;border-left:6px solid var(--ink);padding:12px 16px;margin:22px 0;background:var(--chip)}
.verdict-k{font-size:.72rem;text-transform:uppercase;letter-spacing:.12em;color:var(--muted)}
.verdict-v{font:500 1.6rem/1.2 var(--serif)}
.edge-safety{border-left-color:#B8412F}.edge-futility{border-left-color:#7A6A9E}.edge-slow_accrual{border-left-color:#3E7C8C}
.edge-funding_business{border-left-color:#C58A2B}.edge-manufacturing_supply{border-left-color:#6C8F4E}.edge-regulatory{border-left-color:#8C5A3C}
.edge-logistics_pi{border-left-color:#4F6FA8}.edge-other,.edge-unspecified{border-left-color:#8A867D}
.autopsy-quote{font:italic 1.35rem/1.4 var(--serif);margin:18px 0 4px;padding:0;color:var(--ink)}
.life-wrap{overflow-x:auto;margin:6px 0}
.life-svg{width:100%;min-width:560px;height:auto;display:block}
.life-axis{stroke:var(--line);stroke-width:2}.life-tick{stroke:var(--line)}.life-stem{stroke:var(--muted);stroke-dasharray:2 3}
.life-year{fill:var(--muted);font:11px var(--sans)}.life-label{fill:var(--ink);font:600 12px var(--sans)}.life-date{fill:var(--muted);font:11px var(--sans)}
.life-bar{opacity:.9}.life-bar.planned{fill:transparent;stroke:var(--muted);stroke-dasharray:4 3}
.life-dot{fill:var(--bg);stroke:var(--ink);stroke-width:2.5}.life-dot.end{fill:#B8412F;stroke:#B8412F}.life-dot.planned{stroke:var(--muted);stroke-dasharray:2 2}
.life-story{padding-left:20px}
.fine{font-size:.85rem;color:var(--muted)}
.pm-form{display:grid;gap:12px;grid-template-columns:1fr;margin:14px 0}
@media (min-width:820px){.pm-form{grid-template-columns:repeat(3,1fr)}}
.pm-form label{display:flex;flex-direction:column;gap:4px;font-size:.85rem;color:var(--muted)}
.pm-form input[type=number]{height:46px;padding:0 14px;font:inherit;color:var(--ink);background:transparent;border:1px solid var(--line);border-radius:2px;width:100%}
.pm-head{font:500 clamp(1.4rem,3vw,2rem)/1.2 var(--serif);margin:24px 0 6px}
.pm-bars{display:grid;gap:8px;margin:14px 0}
.pm-row{display:grid;grid-template-columns:minmax(120px,190px) 1fr 70px;gap:10px;align-items:center;font-size:.9rem}
.pm-track{height:14px;background:var(--chip);position:relative}
.pm-svg{width:100%;height:14px;display:block}
.pm-mult{font-size:.8rem;color:var(--muted);text-align:right}
.pm-mult.hot{color:#B8412F;font-weight:600}
.pm-grid{display:grid;gap:16px;grid-template-columns:1fr;margin-top:16px}
@media (min-width:820px){.pm-grid{grid-template-columns:repeat(3,1fr)}}
.pm-stat{border-top:2px solid var(--ink);padding-top:8px}.pm-stat strong{display:block;font:500 1.8rem var(--serif)}
.tl-bar{display:flex;flex-wrap:wrap;align-items:center;gap:12px;margin:14px 0}
.tl-year{font:500 2.4rem/1 var(--serif);min-width:3ch}
.tl-bar input[type=range]{flex:1;min-width:180px;accent-color:var(--ink)}
.wr-pick{display:grid;gap:12px;grid-template-columns:1fr;margin:14px 0}
@media (min-width:820px){.wr-pick{grid-template-columns:180px 1fr auto}}
.wr-stage{position:relative;border:2px solid var(--ink);background:var(--ink);color:var(--bg);min-height:360px;padding:34px 30px 70px;margin-top:18px;overflow:hidden}
.wr-stage.c-safety,.wr-stage.c-futility,.wr-stage.c-slow_accrual,.wr-stage.c-funding_business,.wr-stage.c-manufacturing_supply,.wr-stage.c-regulatory,.wr-stage.c-logistics_pi,.wr-stage.c-other{color:#FFF;border-color:transparent}
.wr-stage.c-safety{background:#B8412F}.wr-stage.c-futility{background:#7A6A9E}.wr-stage.c-slow_accrual{background:#3E7C8C}.wr-stage.c-funding_business{background:#C58A2B}.wr-stage.c-manufacturing_supply{background:#6C8F4E}.wr-stage.c-regulatory{background:#8C5A3C}.wr-stage.c-logistics_pi{background:#4F6FA8}.wr-stage.c-other{background:#8A867D}
.wr-dots{display:flex;gap:6px;margin-bottom:26px}.wr-dot{flex:1;height:3px;background:currentColor;opacity:.3}.wr-dot.on{opacity:1}
.wr-kick{font-size:.78rem;text-transform:uppercase;letter-spacing:.14em;opacity:.8;margin:0 0 8px}
.wr-big{font:500 clamp(2.6rem,9vw,5.4rem)/1 var(--serif);margin:6px 0 14px;overflow-wrap:anywhere}
.wr-text{font:500 clamp(1.2rem,3vw,1.7rem)/1.3 var(--serif);margin:0 0 10px;max-width:30ch}
.wr-small{font-size:.92rem;opacity:.85;max-width:60ch}
.wr-quote{font:italic clamp(1.2rem,3vw,1.6rem)/1.35 var(--serif);margin:10px 0}
.wr-nav{position:absolute;left:30px;right:30px;bottom:20px;display:flex;justify-content:space-between;gap:10px}
.wr-nav .btn{background:transparent;color:inherit;border:1px solid currentColor}
.wr-anim{animation:wrIn .45s ease-out}
@keyframes wrIn{from{opacity:0;transform:translateY(14px)}to{opacity:1;transform:none}}
@media (prefers-reduced-motion:reduce){.wr-anim{animation:none}}