Sickle Cell Disease

Why trials studying Sickle Cell Disease stopped, in this sample of ClinicalTrials.gov.

21 stopped trials with a clear reason; 90% ended for non-scientific reasons.

Trials

• Prophylactic Transfusion In Pregnant in Women With Sickle Cell Disease
  NCT06979492 · WITHDRAWN · slow accrual
  “The study was withdrawn due to no enrollment”
• The Sequestration of Holistic Stress Management Techniques for Adults
  NCT06098755 · WITHDRAWN · slow accrual
  “No Participants Enrolled”
• Single-dose Pharmacokinetics of Pociredir in Participants With Sickle Cell Disease
  NCT07431398 · TERMINATED · funding business
  “Sponsor decision”
• Biotin-Acridine Red Cell Exchange Kinetics
  NCT07155031 · WITHDRAWN · funding business
  “This study has been suspended due to a lack of funding. The protocol will be reconsidered within the next 6-12 months if/as funding becomes available.”
• GBT021601-022: A Study of GBT021601 in Participants With Sickle Cell Disease (SCD)
  NCT05632354 · TERMINATED · other
  “Study terminated as data obtained from this non-placebo-controlled trial may not be informative for the interpretation of the benefits and risks of osivelotor”
• Prospective, Observational Study in Sickle Cell Disease Patients on Crizanlizumab Treatment in Middle East Countries and India
  NCT05020873 · TERMINATED · funding business
  “sponsor decision”
• Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease
  NCT04218084 · TERMINATED · regulatory
  “Emerging clinical data evaluated by Pfizer and shared with regulatory authorities indicates that the risk profile of voxelotor in people with SCD exceeds the benefits observed in previously generated global research and requires further assessment.”
• Dose Escalation Study to Evaluate the Safety, Tolerability, PK and PD of Voxelotor in Patients With SCD
  NCT04247594 · TERMINATED · funding business
  “Data will not inform further development of Voxelotor”
• Near Infrared Spectroscopy in Sickle Cell Pediatric Patients
  NCT04031521 · WITHDRAWN · slow accrual
  “No eligible patient were available/ found”
• Acceptability, Feasibility and Safety of a Yoga Program for Chronic Pain in Sickle Cell Disease
  NCT03694548 · TERMINATED · logistics pi
  “Study terminated due to COVID-19 pandemic.”
• Stem Cell Transplant in Patients With Severe Sickle Cell Disease
  NCT03421756 · TERMINATED · slow accrual
  “Trial terminated due to low rate of enrollment”
• Role of Virtual Reality (VR) in Patients With Sickle Cell Disease (SCD)
  NCT03387033 · TERMINATED · funding business
  “enrollment closed due to lack of funding”
• A Pilot Study of Azithromycin Prophylaxis for Acute Chest Syndrome in Sickle Cell Disease
  NCT02630394 · WITHDRAWN · logistics pi
  “Principal Investigator has moved to another institution”
• Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other Anemias
  NCT02041299 · TERMINATED · other
  “Difficulties with additional recruitment as pool of potential patients was exhausted, and sufficient information for determination of study outcome measure was already obtained”
• Androgen Regulation of Priapism in Sickle Cell Disease
  NCT01940718 · WITHDRAWN · funding business
  “Funding could not be secured”
• Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease
  NCT01987908 · TERMINATED · funding business
  “Study was terminated early by the Sponsor due to unblinding between study drug and placebo groups at the subject, site and Sponsor levels.”
• Low-Dose Ketamine Infusion for Children With Sickle Cell Disease-Related Pain
  NCT00595530 · TERMINATED · slow accrual
  “Lack of enrollment and patient interest in study”
• SALT: Alternative Donor Bone Marrow and Cord Blood Transplantation for High Risk Sickle Cell Disease
  NCT00257543 · TERMINATED · slow accrual
  “lack of enrollment”
• Steroid Treatment for Sickle Cell Pain Crisis
  NCT00263562 · TERMINATED · slow accrual
  “poor enrollment, availability of more effective medications”
• Inhaled Nitric Oxide for Pediatric Painful Sickle Crisis
  NCT00142051 · TERMINATED · slow accrual
  “18 or 20 enrolled, stopped due to paucity of available participants”
• A Pilot Study of Chronic Red Blood Cell Transfusion in Sickle Cell Disease-Associated Pulmonary Hypertension
  NCT00850369 · WITHDRAWN · slow accrual
  “Slow accrual onto the study”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.