Sepsis

Why trials studying Sepsis stopped, in this sample of ClinicalTrials.gov.

22 stopped trials with a clear reason; 82% ended for non-scientific reasons.

Trials

• Mitochondrial Dysfunction Contributes to Sepsis Induced Cardiac Dysfunction
  NCT05148117 · WITHDRAWN · regulatory
  “Could not get through IRB submission and co-investigators with needed skillsets for study departed organization”
• Rezafungin Pharmacokinetics in Patients on ECMO
  NCT06329518 · WITHDRAWN · logistics pi
  “PI departure”
• Integrated Clinical Decision Support for Empiric Antibiotic Selection in Sepsis
  NCT06103500 · TERMINATED · funding business
  “Funding.”
• High-dose Intravenous Vitamin C as an Adjunctive Treatment for Sepsis in Rwanda
  NCT04088591 · WITHDRAWN · safety
  “Recent studies suggest an increase in mortality due to high-does Vitamin C”
• HAT for the Treatment of Sepsis Associated With NASTI
  NCT05157360 · TERMINATED · slow accrual
  “slow recruitment and not anticipated to meet recruitment numbers”
• Physiological Effects of 38°C vs. 22°C Fluid Therapy in Critically Ill Patients
  NCT04576806 · WITHDRAWN · logistics pi
  “Other research priorities during Covid-19 pandemic.”
• Impact of COVID-19 on the Incidence, Characteristics, Management and Outcome of Sepsis
  NCT04698382 · WITHDRAWN · logistics pi
  “Reduced relevance due to end of pandemic”
• Collective Accuryn Physiologic Signals and Signatures
  NCT03817281 · WITHDRAWN · slow accrual
  “Lack of Enrollment”
• Procalcitonin and Antimicrobial Utilization in Critically Ill Cancer Patients with Sepsis
  NCT04203524 · TERMINATED · futility
  “No significant differences between 2 study arms”
• LifeFlow Sepsis Study
  NCT07191054 · WITHDRAWN · slow accrual
  “Study never started, no enrollments.”
• ASpirin for Patients With SEPsis and SeptIc Shock
  NCT01784159 · TERMINATED · safety
  “Terminated: The study was stopped prematurely and will not be resumed due to the higher number of bleeding cases in the intervention group, as recomended by the Data Safety Monitoring Board on February 7, 2023.”
• Flow Cytometry Analysis of the Reactive Oxygen Species in Immature Granulocytes in Septic Patient
  NCT03846596 · TERMINATED · slow accrual
  “Not enough patient”
• Project 4A: Inspiratory Muscle Training and Diaphragm Strength
  NCT02367170 · TERMINATED · slow accrual
  “Unable to recruit sufficient number of patients”
• Single Dose Enteral Tranexamic Acid in Critically Ill Patients
  NCT01683747 · TERMINATED · slow accrual
  “Lower than anticipated enrollment”
• The Effect of Erythropietin on Microcircualtory Alteration in Intensive Care Unit Patients With Severe Sepsis
  NCT01087450 · TERMINATED · slow accrual
  “Lack of recruitment”
• Hepatic Mitochondrial Function in Sepsis
  NCT00889083 · WITHDRAWN · slow accrual
  “no patients to include”
• Albumin Administration in Cirrhotic Patients With Bacterial Infection and a Systemic Inflammatory Response Syndrome Unrelated to Spontaneous Bacterial Peritonitis
  NCT01359813 · TERMINATED · futility
  “decision of independent monitoring committee:Risk of death at 3 months higher in Albumin group than in control group, without reaching significance level.”
• Methylene Blue in Sepsis: A Randomized Controlled Trial
  NCT00486174 · WITHDRAWN · logistics pi
  “primary site withdrew due to competing study: never enrolled any subjects.”
• Probiotic Administartion to Mothers of Preterm Infants to Prevent Necrotizing Enterocolitis and Sepsis
  NCT00835874 · TERMINATED · slow accrual
  “Difficulty in recruitment. Mothers of infants preferred to take probiotics bought over-the-counter over the possibility of being in a placebo group”
• Fluconazole Versus Micafungin for Candida Bloodstream Infection in Non-Neutropenic Patients
  NCT00304772 · WITHDRAWN · slow accrual
  “Subjects were not recruited as intended.”
• Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity
  NCT00303082 · TERMINATED · funding business
  “Limitation of funding”
• Studies of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome
  NCT00159510 · TERMINATED · slow accrual
  “Inability to recruit the patients due to the short supply and changed local hospital protocol”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.