Schizophrenia

Why trials studying Schizophrenia stopped, in this sample of ClinicalTrials.gov.

44 stopped trials with a clear reason; 95% ended for non-scientific reasons.

Trials

• Evaluation Study of New Compounds With Potential Use in Schizophrenia
  NCT00916201 · WITHDRAWN · funding business
  “Lack of funding”
• Horyzons: Implementation and Integration in Clinical Practice
  NCT06002958 · TERMINATED · funding business
  “Reductions in available funding”
• Deep rTMS Modulating Insula Synaptic Density and Smoking Behavior in Schizophrenia
  NCT05724810 · TERMINATED · funding business
  “Funding was not renewed.”
• Exercise Target Brain Oscillations in Psychosis
  NCT05338424 · WITHDRAWN · logistics pi
  “Principal Investigator left the institution”
• A Clinical Trial to Evaluate the Long-term Safety and Tolerability of SEP-363856 in Patients With Schizophrenia in Japan
  NCT05359081 · TERMINATED · funding business
  “Due to company business strategy”
• A Pharmaco-imaging Approach to Predicting Social Functioning and Clinical Responses to Oxytocin Administration in Schizophrenia
  NCT03900754 · TERMINATED · slow accrual
  “Inadequate Subject Recruitment”
• Effects of Transdermal Nicotine on Response Inhibition to Emotional Cues in Schizophrenia
  NCT03838484 · TERMINATED · logistics pi
  “Recruitment challenges due to Covid19.”
• Telmisartan Pilot Study on Treatment Resistant Schizophrenia
  NCT03868839 · TERMINATED · funding business
  “Lack of funding”
• Study With Lu AF11167 for the Treatment of Negative Symptoms in Patients With Schizophrenia
  NCT03793712 · TERMINATED · futility
  “Lack of efficacy based on interim analysis”
• Mindfulness and Cognition in Schizophrenia
  NCT03318640 · TERMINATED · slow accrual
  “low inclusion rates”
• tDCS and Cognitive Training Intervention for Chronic Smokers With Schizophrenia
  NCT03588728 · TERMINATED · logistics pi
  “Lab was shut down due to COVID as were nearing study completion”
• Links Between Perception of Temporal Order Judgment and Causality in Schizophrenia
  NCT03432000 · TERMINATED · logistics pi
  “Investigator departure”
• Naltrexone-Bupropion Versus Placebo-Bupropion for Weight Loss in Schizophrenia
  NCT03132571 · TERMINATED · funding business
  “Study discontinued due to funding.”
• HDAC Inhibitor Augmentation to Clozapine
  NCT03263533 · WITHDRAWN · slow accrual
  “PIs were unable to recruit any participants”
• PET Imaging Study of Amish and Mennonite Patients With CNTNAP2 Mutations
  NCT02983058 · TERMINATED · funding business
  “To obtain funding for a larger study”
• Aripiprazole, Abilify Maintena Collaborative Clinical Protocol
  NCT02717130 · TERMINATED · slow accrual
  “The study was terminated due to lack of enrollment.”
• Safety, Tolerability, and Pharmacokinetics of APN1125 in Subjects With Schizophrenia
  NCT02724917 · SUSPENDED · funding business
  “Study halted by sponsor for business reasons”
• A Pilot Trial of Curcumin Effects on Cognition in Schizophrenia
  NCT02476708 · TERMINATED · slow accrual
  “Recruitment was not achieved as expected”
• Early and Short Psycho-educational Lifestyle Intervention
  NCT02657941 · TERMINATED · slow accrual
  “inclusion problem”
• Efficiency of Art-therapy in Psychotic Disorders
  NCT02383095 · TERMINATED · slow accrual
  “Difficulties of recruitment”
• tDCS & Auditory Hallucinations in Schizophrenia
  NCT02227563 · TERMINATED · slow accrual
  “Lack of participants that fit inclusion criteria”
• The Efficacy and Safety of a Selective Estrogen Receptor Beta Agonist (LY500307) for Negative Symptoms and Cognitive Impairment Associated With Schizophrenia
  NCT01874756 · TERMINATED · funding business
  “Funding ended”
• Non-Invasive Brain Stimulation for Medication-Resistant Auditory Hallucinations in Schizophrenia Patients
  NCT02240446 · WITHDRAWN · other
  “Will no longer be conducted. We have started a different project.”
• Phase I Study to Evaluate the Safety and Pharmacokinetics of Oral Doses of Anvylic-3288 in Healthy Subjects
  NCT01851603 · TERMINATED · logistics pi
  “PI left institution”
• Antipsychotic Discontinuation in High-risk Subjects
  NCT01758887 · WITHDRAWN · logistics pi
  “administrative reason”
• The Effect of Metformin on Obesity and Metabolic Disturbance in Patients Taking Clozapine
  NCT01654640 · TERMINATED · slow accrual
  “Failure to recruit the planned number of participants”
• A Long-Term Safety Study of Pomaglumetad Methionil in Schizophrenia
  NCT01487083 · TERMINATED · funding business
  “The decision to stop the trial was based on efficacy results in the overall schizophrenia participant population.”
• Antipsychotic Effects of Oxytocin
  NCT01621737 · TERMINATED · funding business
  “Break in funding”
• Effects of Metformin and Fish Oil on Treatment With Clozapine
  NCT02140788 · TERMINATED · logistics pi
  “PI left institution”
• A Comparison Study of LY2140023 and Aripiprazole in Schizophrenia Patients
  NCT01328093 · TERMINATED · funding business
  “The decision to stop the trial was based on efficacy results in the overall schizophrenia participant population.”
• Treating Refractory Schizophrenia With rTMS
  NCT02242578 · TERMINATED · regulatory
  “IRB approval expired and study ceased.”
• A Long-Term, Open-Label, Study on Schizophrenia
  NCT01129674 · TERMINATED · funding business
  “The decision to stop the trial was based on efficacy results in the overall schizophrenia participant population.”
• A Study in Schizophrenic Patients
  NCT01125358 · TERMINATED · funding business
  “The decision to stop the trial was based on efficacy results in the overall schizophrenia participant population.”
• 28-30 Month Study Comparing Paliperidone Palmitate With Oral Risperidone for Treating Adults Diagnosed With Schizophrenia Within the Past 5 Years
  NCT00946985 · TERMINATED · slow accrual
  “The recruitment rate for the study was inadequate to achieve its enrollment goals.”
• Trial Comparing the Effects of Aripiprazole With Those of Standard of Care on Non-HDL Cholesterol in Patients With Schizophrenia or Bipolar I Disorder Who Have Metabolic Syndrome
  NCT00857818 · TERMINATED · slow accrual
  “Slow Accrual”
• Seroquel XR in Adults With Schizophrenia
  NCT00852631 · TERMINATED · slow accrual
  “The study was prematurely terminated due to insufficient recruitment.”
• The Effect of Sertindole and Risperidone on Endophenotypic Markers of Schizophrenia
  NCT02021201 · TERMINATED · slow accrual
  “No suitable patients could be recruited in the available time period”
• Metformin for Weight Loss in Schizophrenia
  NCT01177709 · TERMINATED · logistics pi
  “PI moved to different institution. Decided to concentrate on different studies.”
• Safety and Tolerability of Varenicline in Schizophrenia (SATOVA)
  NCT00702793 · WITHDRAWN · slow accrual
  “No participants enrolled”
• The Effect of Sertindole on Sensory Gating and Cognition in Schizophrenic Patients
  NCT00629252 · TERMINATED · slow accrual
  “Not enough subjects have been recruited in the expected period.”
• A Placebo-controlled Efficacy Study of IV Ceftriaxone for Refractory Psychosis
  NCT00591318 · TERMINATED · slow accrual
  “Study was terminated after enrolling 12 patients due to poor enrollment rates”
• An Observational Study to Evaluate Efficacy and Safety of Risperidone Long-Acting Injection for Treatment of Schizophrenia
  NCT01894984 · TERMINATED · slow accrual
  “The study was terminated because of high dropout rate.”
• Cognitive Improvement With Aripiprazole (Abilify) in Patients With Schizophrenia (BMS)
  NCT00211302 · TERMINATED · slow accrual
  “Enrollment too difficult”
• Modulation of Regional Brain Activation in Schizophrenic Patients by Pharmacological Therapy
  NCT00419653 · TERMINATED · slow accrual
  “Recruitment issues”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.