Prostate Cancer

Why trials studying Prostate Cancer stopped, in this sample of ClinicalTrials.gov.

84 stopped trials with a clear reason; 87% ended for non-scientific reasons.

Trials

• Efficacy, Safety, and Pharmacokinetics of FP-014, 22.5 mg in Patients With Advanced Prostate Cancer
  NCT06795191 · WITHDRAWN · funding business
  “Business reasons not safety related.”
• Neoadjuvant SGLT2 Inhibition in Localized Prostate Cancer
  NCT04887935 · TERMINATED · slow accrual
  “Low accrual”
• A Neoadjuvant Study of Abiraterone Acetate, Leuprolide Acetate, and Belzutifan in Men With Regional Prostate Cancer
  NCT05574712 · WITHDRAWN · logistics pi
  “Principal Investigator has decided not to activate this trial.”
• Study of XNW5004 Tablet in Combination With KEYTRUDA® (Pembrolizumab) in Subjects With Advanced Solid Tumors Who Failed Standard Treatments (KEYNOTE F19)
  NCT06022757 · TERMINATED · funding business
  “Strategic decision by Sponsor.”
• Investigator Initiated Trial to Further Evaluate the Safety and Efficacy of Trans-perineal Focal Laser Ablation of Localized Prostate Cancer Using High Frequency Micro-ultrasound Imaging
  NCT05826470 · TERMINATED · funding business
  “Business decision of the Sponsor”
• 18F-PSMA PET/MRI for the Diagnosis of Clinically Significant Prostate Cancer
  NCT05815316 · WITHDRAWN · other
  “error in the registration on clincialtrials.gov. The same clinical trial has been correctly registered with the identifier NCT 06305390”
• A Study of Extending Relugolix Dosing Intervals Through Addition of Itraconazole or Ritonavir in Prostate Cancer Patients
  NCT05679388 · TERMINATED · logistics pi
  “Terminated by the PI”
• Retrospective Analysis of 68Ga-PSMA-PET in Patients With Prostate Cancer: Experience From Brazil
  NCT05169372 · TERMINATED · slow accrual
  “LACOG and Astellas decided to end the study due to the great difficulty in finding patients with the desired profile.”
• Safety, Tolerability, Distribution & Dose Effect of Neoadjuvant Transarterial Chemoembolization With Doxorubicin in Prostate Cancer Patients Before Radical Prostatectomy
  NCT04423913 · TERMINATED · slow accrual
  “Recruitment difficulties”
• Apalutamide Plus Cetrelimab in Patients With Treatment-Emergent Small Cell Neuroendocrine Prostate Cancer
  NCT04926181 · TERMINATED · funding business
  “Funding”
• EPI-7386 in Combination with Enzalutamide Compared with Enzalutamide Alone in Subjects with MCRPC
  NCT05075577 · TERMINATED · futility
  “Study was terminated early due to a lack of improved efficacy.”
• Study of Focal Ablation of the Prostate With NanoTherm® Therapy System for Intermediate-Risk Prostate Cancer
  NCT05010759 · TERMINATED · slow accrual
  “Inadequate enrollment and company changing direction”
• Spermine Measuring Device Evaluation Protocol
  NCT04339920 · WITHDRAWN · funding business
  “No funding”
• Diagnostic Performance of PSMA PET/CT for Pre-operative Lymph Node Assessment in Intermediate and High-risk Non-metastasic Prostate Cancer (PREOP-PSMA ).
  NCT04745871 · TERMINATED · regulatory
  “In the PREOP-PSMA protocol, written before 68Ga-PSMA-11 obtained Marketing Authorization. Today, PSMA PET/CT has become routine and is performed before MTB review.”
• 18F-DCFPyL Positron Emission Tomography (PET) in Intermediate or High Risk Prostate Cancer
  NCT04727736 · TERMINATED · regulatory
  “Intervention became FDA-approved”
• In Situ Clonal Heterogeneity in Prostatic Diagnostic Biopsies
  NCT04873427 · TERMINATED · slow accrual
  “The results of the genomic analyses were compromised due to the low DNA concentration.”
• Cabozantinib in Patients With Metastatic Castrate Resistant Prostate Cancer (mCRPC)
  NCT04631744 · TERMINATED · slow accrual
  “Low accrual”
• Study of CYH33 in Combination With Olaparib an Oral PARP Inhibitor in Patients With Advanced Solid Tumors.
  NCT04586335 · TERMINATED · funding business
  “Business decision”
• Focal Therapy for Localized Prostate Cancer
  NCT03970863 · WITHDRAWN · slow accrual
  “difficulty in recruiting participants”
• Two TraCer PositROn EmiSSion Tomography ComBination for Efficacy EstimatiOn of Prostate Specific Membrane Antigen Radioligand Therapy in Patients With Metastatic Prostate Cancer
  NCT04085991 · TERMINATED · manufacturing supply
  “Drug no longer available”
• Immediate Prostatectomy vs. Cabozantinib Followed by Prostatectomy in Men With High-Risk Prostate Cancer
  NCT03964337 · TERMINATED · slow accrual
  “Poor accrual.”
• Augmented BLAdder NecK rEconstruction Trial for Improved Urinary Function After Radical Prostatectomy
  NCT04305379 · TERMINATED · logistics pi
  “Stopped due to COVID-19 pandemic, low priority among initiatives and officially terminated.”
• (SGB) in Men Treated for Prostate Cancer Improve Hot Flashes
  NCT03796195 · TERMINATED · slow accrual
  “Enrollment issues”
• Study of 18F-DCFPyL PET/CT Imaging in Patients With Prostate Cancer
  NCT03800784 · WITHDRAWN · funding business
  “Lack of funding”
• Study With Bispecific Antibody Engaging T-cells, in Patients With Progressive Cancer Diseases With Positive PSCA Marker
  NCT03927573 · TERMINATED · funding business
  “business decision by sponsor”
• A Study of SHR3680 in Combination With SHR3162 in the Treatment of mCRPC
  NCT04102124 · TERMINATED · funding business
  “The sponsor's R\&D strategy is adjusted.”
• A Parallel Arm Phase 1b/2a Study of DKN-01 as Monotherapy or in Combination With Docetaxel for the Treatment of Advanced Prostate Cancer With Elevated DKK1
  NCT03837353 · TERMINATED · slow accrual
  “Terminated early due to slow accrual in the context of changing practice patterns.”
• Effect of Perioperative Intravenous Lidocaine Infusion in Robotic-Assisted Urologic Surgery
  NCT03824808 · TERMINATED · slow accrual
  “Challenges with recruitment of surgical research subjects in the target population.”
• Rucaparib and Nivolumab in Patients With Prostate or Endometrial Cancer
  NCT03572478 · TERMINATED · futility
  “The study was terminated due to lack of efficacy.”
• Metformin in Patients Initiating ADT as Prevention and Intervention of Metabolic Syndrome
  NCT03031821 · TERMINATED · manufacturing supply
  “Manufacturer discontinued the production of study drugs.”
• BrUOG 337: Olaparib Prior to Radical Prostatectomy For Advanced Prostate Cancer Defects in DNA Repair Genes
  NCT03432897 · TERMINATED · slow accrual
  “Lack of enrollment secondary to eligibility criteria”
• A Prospective, Randomized Trial Comparing Office-based MR-guided Prostate Biopsy Approaches
  NCT03632655 · TERMINATED · funding business
  “The study was terminated due to procurement of new funding sources.”
• SAKK 08/15 - PROMET - Salvage Radiotherapy +/- Metformin for Patients With Prostate Cancer After Prostatectomy
  NCT02945813 · TERMINATED · slow accrual
  “Trial was prematurely closed for accrual by the SAKK Board and the follow-up period shortened to one year after last RT fraction of the last patient”
• Correlation of Imaging Findings With Clinical Findings and Patient Outcomes in Prostate Cancer
  NCT03122470 · WITHDRAWN · logistics pi
  “PI departure - study not conducted.”
• Hyperpolarized Carbon-13 Imaging of Metastatic Prostate Cancer
  NCT02844647 · TERMINATED · slow accrual
  “Lack of participants”
• Glycosylation of Exosomes in Prostate and Urothelial Carcinoma
  NCT04960956 · TERMINATED · slow accrual
  “Could not identify a replacement Principal Investigator.”
• Randomized Trial of Image -Guided Stereotactic Radiation Therapy (IG-SRT) in Prostate Cancer
  NCT02911922 · TERMINATED · slow accrual
  “Lack of patient accruals.”
• Investigation of Metformin in Patients With Castration Resistant Prostate Cancer in Combination With Enzalutamide vs. Enzalutamide Alone
  NCT02640534 · TERMINATED · other
  “The decision is based on the fact that with the current follow up of around 10 years, the relevant secondary endpoints can adequately be addressed according to protocol. The addition of follow up data will not significantly impact these results.”
• Miami Membrane for Potency (MMEP) Trial
  NCT02710422 · TERMINATED · slow accrual
  “Lack of Accrual and Inadequate Funding”
• Impact of Anticoagulants and Antiplatelets in Patients on Transurethral Resection of the Prostate
  NCT02822963 · WITHDRAWN · funding business
  “No funding”
• Measuring the Effect of Radiation Therapy on Patient Activity Levels
  NCT02694380 · TERMINATED · slow accrual
  “Low accrual”
• Orteronel Maintenance Therapy in Patients With mCRPC Previously Treated With Novel Hormonal Agents
  NCT02053311 · WITHDRAWN · futility
  “Due to former trials, drug has not demonstrated a clinical profile sufficient to move forward in mCRPC”
• PET/MR Assessment of Sipuleucel T Treatment for Metastatic Castration Resistant Prostate Cancer
  NCT02042053 · TERMINATED · logistics pi
  “Due to PI leaving the institution”
• Tivozanib + Enzalutamide in Adv Prostate Cancer
  NCT01885949 · TERMINATED · slow accrual
  “Slow accrual”
• Safety Study of Pelvic and Prostatic SIB-IMRT With Long-term Androgen Deprivation for High Risk Localized Prostate Cancer
  NCT01704027 · TERMINATED · futility
  “termination of the trial after interim analysis. the main criterion could not be reached”
• Multiparametric MRI for Prostate Cancer Localization and Characterization: New Methods
  NCT01761812 · TERMINATED · slow accrual
  “Inadequate accrual”
• GP Extended Action Triptorelin
  NCT01673984 · TERMINATED · funding business
  “The study was discontinued prematurely by the sponsor due to non-medical reasons”
• A Pilot Trial of Interpersonal Psychotherapy for the Treatment of Depression in Patients With Prostate, Colorectal, Lung and Pancreatic Cancer
  NCT01940237 · TERMINATED · slow accrual
  “Low recruitment”
• 11C Acetate Imaging Post Prostatectomy
  NCT01602783 · TERMINATED · slow accrual
  “Slow accrual; no further funding”
• Transrectal Photoacoustic Imaging of the Prostate
  NCT02365883 · TERMINATED · logistics pi
  “PI passed away”
• Study of Lanreotide in Non Metastatic Castration-resistant Prostate Cancer Patients
  NCT01313273 · TERMINATED · slow accrual
  “Poor enrolment”
• Pasireotide (SOM230) With or Without Everolimus in Treating Patients With Hormone Resistant, Chemotherapy Naive Prostate Cancer
  NCT01313559 · TERMINATED · slow accrual
  “Slow accrual”
• Metformin With Standard Taxotere and Prednisone in the Treatment of Castration Resistant Prostate Cancer
  NCT01478308 · WITHDRAWN · slow accrual
  “No accrual in initial period, PI decided to close study.”
• Study of Itraconazole in Castrate-resistant Prostate Cancer (CRPC) Post-chemotherapy
  NCT01450683 · TERMINATED · slow accrual
  “Low accrual”
• Changes in Brown Adipose Tissue Activity In Men Receiving Androgen Deprivation Therapy for Prostate Cancer
  NCT01226888 · TERMINATED · slow accrual
  “Slow accrual”
• Feasibility and Safety Study Using Preoperative High-Dose Single-Fraction Image-Guided Radiotherapy for Men Undergoing Radical Prostatectomy at High-Risk for Extraprostatic Cancer
  NCT01163448 · WITHDRAWN · slow accrual
  “Lack of accrual”
• Radiation Therapy and Ixabepilone in Treating Patients With High-Risk Stage III Prostate Cancer After Surgery
  NCT01079793 · WITHDRAWN · logistics pi
  “Overlapping study, PI preferred to enroll in alternate trial.”
• Ketoconazole, Hydrocortisone, Dutasteride and Lapatinib (KHAD-L) in Prostate Cancer
  NCT00953576 · TERMINATED · safety
  “The study terminated early due to concerns about drug toxicity.”
• Genomic Guided Therapy With Dasatinib or Nilutamide in Metastatic Castration-Resistant Prostate Cancer
  NCT00918385 · TERMINATED · funding business
  “Permanent closure of trial to further accrual based on IDE disapproval”
• Vaccine Therapy in Treating Patients With Non-Metastatic Prostate Cancer
  NCT00814892 · TERMINATED · funding business
  “Study was terminated due to funding issues.”
• Biomarker Study of Neoadjuvant Vitamin E in Patients With Locally Treatable Prostate Cancer
  NCT00809458 · TERMINATED · slow accrual
  “Low rate of accrual.”
• S0716 Vandetanib and Docetaxel in Treating Patients With Advanced Solid Tumors
  NCT00937417 · WITHDRAWN · other
  “Withdrawn because SWOG no longer pursuing this study at this time”
• CP-675,206 in Combination With Short Term Androgen Deprivation in Patients With Stage D0 Prostate Cancer
  NCT00702923 · TERMINATED · slow accrual
  “Enrollment was halted prematurely due to slow accrual.”
• Implant Radiation Therapy or Surgery in Treating Patients With Prostate Cancer
  NCT01098331 · TERMINATED · slow accrual
  “Closed early due to poor recruitment”
• A Phase III Trial of ZD4054 (Zibotentan) (Endothelin A Antagonist) in Non-metastatic Hormone Resistant Prostate Cancer
  NCT00626548 · TERMINATED · futility
  “early efficacy review by the Independent Data Monitoring Committee indicated it was unlikely to meet its primary efficacy endpoints”
• Radiation Therapy Followed by Surgery in High-Risk, Localized Carcinoma of the Prostate
  NCT00691977 · WITHDRAWN · slow accrual
  “poor accrual”
• Sandostatin for Patients With Androgen Independent Prostate Cancer
  NCT00510224 · TERMINATED · futility
  “Stopped at interim analyses phase due to lack of efficacy”
• Urodynamic Evaluation in Post-radiation Salvage Prostatectomy Patients
  NCT00901420 · TERMINATED · slow accrual
  “Terminated due to slow accrual.”
• A Phase I/II Study of Azacitidine, Docetaxel, and Prednisone for Metastatic Prostate Cancer Patients
  NCT00503984 · TERMINATED · funding business
  “Withdrawal of Funding”
• Soy Protein/Effexor Hormone Therapy for Prostate Cancer
  NCT00354432 · TERMINATED · futility
  “Stopped by the DSMB for lack of effect per interim stopping rule.”
• Observation of Outcomes and Side Effects of Cesium-131 in Combination With External Beam Radiation for the Treatment of Intermediate to High Risk Prostate Cancer
  NCT00621413 · WITHDRAWN · slow accrual
  “Study never moved forward due to no accrual”
• Pilot Study of (61)CuATSM-PET Imaging in Cancer Patients
  NCT00585117 · TERMINATED · funding business
  “change in imaging priorities”
• Quality of Life in Men With High Risk Localized Prostate Cancer
  NCT00877617 · WITHDRAWN · slow accrual
  “Slow accrual”
• Can Tadalafil Maintain Erectile Function In Patients Treated With Radiotherapy For Prostate Cancer?
  NCT00215631 · TERMINATED · slow accrual
  “slow recruitment”
• Docetaxel, Prednisone, and Vatalanib in Treating Patients With Advanced Prostate Cancer
  NCT00293371 · TERMINATED · slow accrual
  “low accrual”
• Flu/TBI in Treating Patients Not Responding to Previous Hormone Therapy
  NCT00242931 · WITHDRAWN · slow accrual
  “Unable to successfully recruit subjects to this study.”
• Calcitriol in Preventing Prostate Cancer in Patients With Prostatic Intraepithelial Neoplasia
  NCT00118066 · TERMINATED · slow accrual
  “Slow accruaL, lack of scientific progress”
• Gefitinib and Etoposide in Treating Patients With Advanced Prostate Cancer That Did Not Respond to Hormone Therapy
  NCT00483561 · TERMINATED · logistics pi
  “PI left UNMC”
• ZOMETA® (Zoledronic Acid) for Prevention of Bone Metastases
  NCT00294437 · TERMINATED · funding business
  “underfunding”
• Extension Study Investigating the Long-Term Safety and Tolerability of Repeat Doses of FE200486 in Prostate Cancer Patients
  NCT00117312 · TERMINATED · logistics pi
  “After 190 weeks \[7 patients left\] it was terminated for administrative reasons”
• Comparison of Trelstar Versus Lupron or Zoladex in Advanced Prostate Cancer
  NCT02749825 · TERMINATED · funding business
  “Withdrawal of funding support”
• Bicalutamide Compared With Observation Followed by Bicalutamide Plus Either Goserelin or Orchiectomy in Treating Patients With Prostate Cancer
  NCT00014586 · TERMINATED · slow accrual
  “low accrual”
• Botulinum Toxin Injection With Prostate Brachytherapy
  NCT00681148 · WITHDRAWN · funding business
  “No funding”
• A Study of Dovitinib With Androgen Deprivation Therapy (ADT) in Patients With Metastatic Prostate Cancer Receiving Primary ADT
  NCT02065323 · WITHDRAWN · funding business
  “Terminated due to budgetary considerations and length of development.”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.