Pain

Why trials studying Pain stopped, in this sample of ClinicalTrials.gov.

44 stopped trials with a clear reason; 91% ended for non-scientific reasons.

Trials

• Prescribing Lorazepam for IUD Insertion: Pilot Feasibility Study
  NCT06496854 · WITHDRAWN · logistics pi
  “Unable to coordinate logistics”
• A Dose-Finding Study to Evaluate the Efficacy and Safety of GSK3858279 in Adults With Knee Osteoarthritis (OA) Pain
  NCT05838742 · TERMINATED · futility
  “The study met futility criteria at pre-planned interim analysis, showing no clinical efficacy of the investigational drug. Based on the lack of efficacy at the interim data review, the sponsor decided to terminate the study.”
• Prophylactic Analgesic and Antiemetic Regimen for Medical Abortion < 70 Days
  NCT05819619 · TERMINATED · slow accrual
  “Inability to recruit and staffing changes”
• Training of Arms to Reduce Pain With Peripheral Venous Catheter
  NCT05716217 · TERMINATED · slow accrual
  “Changes in provision of chemotherapy have made it impossible to recruit patients according to the protocol”
• Impacts of a Standardized Musical Intervention on Complex Dressing Care During Home Hospitalization (MUCAFOCSS)
  NCT04038593 · WITHDRAWN · logistics pi
  “COVID”
• Virtual Reality Decreases Child Anxiety and Pain as Well as Caregiver Anxiety and Pain Perception During Orthopaedic Clinic Office Procedures
  NCT05708586 · TERMINATED · futility
  “Preliminary findings showed no significant difference between virtual reality and distraction techniques.”
• Recognizing Pain Intensity in Alzheimer's Disease
  NCT04614532 · TERMINATED · slow accrual
  “Reduced recruitment potential for study participants.”
• Effects of Intravenous GSK3858279 on a Battery of Evoked Pain Tests in Healthy Volunteers
  NCT04114656 · TERMINATED · futility
  “This study was terminated due to meeting protocol defined futility.”
• Reactive vs. Proactive Pain Control in IBD
  NCT03798405 · TERMINATED · logistics pi
  “COVID-19-related restrictions”
• Rectal Administration of Opioids Using the Macy Catheter in Reducing Pain in Patients With Advanced Cancer
  NCT03592459 · WITHDRAWN · other
  “Study halted prematurely, prior to enrollment of first participant”
• Development of a Morphine Pharmacokinetic and Pharmacodynamic Model for the Neonatal Population
  NCT03035578 · WITHDRAWN · regulatory
  “research project has been abandoned primarily because of the excessive delays associated with past challenges in obtaining approval from Health Canada”
• Multisensory Integration and Pain Perception
  NCT03471689 · WITHDRAWN · logistics pi
  “Resources”
• Acupuncture for Pain in the Emergency Department
  NCT02540512 · WITHDRAWN · slow accrual
  “No participants enrolled”
• Utility of Pharmacogenomic Testing and Postoperative Dental Pain Outcomes
  NCT02932579 · TERMINATED · logistics pi
  “Study was halted permanently due to enrollment and logistic issues.”
• Epidural and Intravenous Patient-Controlled Analgesia Following Lumbar Spinal Fusion Surgery
  NCT03115151 · TERMINATED · slow accrual
  “The surgical team has difficulty to find level 1 and 2 fusions for the study.”
• Tolerability, Safety, and Feasibility of Naloxegol in Patients With Cancer and OIC (Opioid Induced Constipation)
  NCT02839889 · TERMINATED · slow accrual
  “The study was stopped due to challenges recruiting eligible patients.”
• Osteopathic Medicine in the Management of Care-induced Pain in Elderly Care (OGéDIS)
  NCT02584049 · TERMINATED · slow accrual
  “The study was stopped prematurely because of the low inclusion rate (1 inclusion in 16 months), the low patient potential and the difficulty of finding new recruiting centres.”
• Pain in Adults With Autism Spectrum Disorder
  NCT02277756 · TERMINATED · slow accrual
  “autistic recruitment problems”
• Acupuncture for Pain Control in Patients With Inoperable Pancreatic Cancer
  NCT02333409 · TERMINATED · logistics pi
  “Expertise resigned”
• Impact of Liposomal Bupivacaine Administered Following Placement of a Transobturator Suburethral Sling
  NCT02591888 · TERMINATED · slow accrual
  “Difficult to enroll; since a similar research project on a different population showed no significance the study has been closed.”
• Video-based Consensus Opinion for Hand and Upper Extremity Problems
  NCT02204605 · WITHDRAWN · logistics pi
  “The principal investigator left the institution.”
• Effect of Rufinamide on Chronic Postthoracotomy Pain Syndrome
  NCT02095899 · WITHDRAWN · slow accrual
  “Poor study patient recruitment”
• Pain as Indication for Operative Treatment of Traumatic Rib Fractures
  NCT02094807 · WITHDRAWN · slow accrual
  “Slow inclusion rate. Awaiting results from NCT02132416.”
• Buprenorphine vs. Opioid Dose Escalation Among Patients With Chronic Pain
  NCT01875848 · TERMINATED · slow accrual
  “Data safety monitoring board recommended due to low recruitment yield.”
• A Study of Oral Codeine Sulfate in Pediatric Patients With Post-procedural Pain
  NCT01676493 · TERMINATED · slow accrual
  “Decision to stop study due to low recruitment.”
• Immunomodulation, IL-1 Inhibition, and Postoperative Incisional Pain
  NCT01466764 · TERMINATED · slow accrual
  “Due to inability to demonstrate benefit in this patient population.”
• Reducing Immunization Distress (RID)
  NCT01379885 · TERMINATED · slow accrual
  “Estimated sample size not achieved due to decline in number of eligible patients and difficulty recruiting and retaining research staff.”
• Epidural Versus Patient-controlled Analgesia for Reduction in Long-term Mortality Following Colorectal Cancer Surgery
  NCT01318161 · TERMINATED · slow accrual
  “Difficulty in recruiting”
• Discovery Elbow Long-Term Survivorship
  NCT01308463 · TERMINATED · funding business
  “Study terminated due to change in sponsorship”
• Role of Biomarkers in Muscle Pain and Joint Pain in Patients With Solid Tumors Receiving Paclitaxel
  NCT01096407 · TERMINATED · slow accrual
  “slow accrual”
• Calcium and Magnesium in Preventing Peripheral Neuropathy Caused by Ixabepilone in Patients With Breast Cancer
  NCT00998738 · TERMINATED · slow accrual
  “lack of accrual”
• A Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-42160443 in Patients With Neuropathic Pain (Postherpetic Neuralgia and Post-traumatic Neuralgia)
  NCT00964990 · TERMINATED · regulatory
  “Logistic reasons associated with the FDA-imposed clinical hold.”
• Sleep and Endometrial Cancer
  NCT00936598 · TERMINATED · slow accrual
  “Investigator-initiated termination of approval due to problems with recruitment.”
• J-Tip® Jet Injection of 1% Buffered Lidocaine or Saline Versus 4% Lidocaine Cream Before Venipuncture or IV Insertion
  NCT00924963 · WITHDRAWN · funding business
  “Study ended due to lack of funding.”
• Phase 3 Study of Local Administration of SKY0402 for Postoperative Analgesia in Subject Undergoing Breast Augmentation
  NCT00813111 · TERMINATED · funding business
  “Sponsor decision, unrelated to safety”
• Efficacy of rTMS (Repetitive Transcranial Magnetic Stimulation) on Patients With Somatoform Pain Disorder
  NCT00726791 · WITHDRAWN · slow accrual
  “patient did not enroll”
• A Prospective Safety Surveillance Study of Fentanyl Iontophoretic Transdermal System (40 Mcg)
  NCT00665522 · TERMINATED · manufacturing supply
  “Study was terminated at the request of the company due to the recall of marketed product in Europe.”
• A Study to Evaluate the Effectiveness and Safety of CG5503 (Tapentadol) in the Treatment of Chronic Tumor Related Pain Compared With Placebo and Morphine
  NCT00505414 · TERMINATED · manufacturing supply
  “Recall of rescue medication, alternative rescue medication availability issues.”
• A Phase I/II Study of Azacitidine, Docetaxel, and Prednisone for Metastatic Prostate Cancer Patients
  NCT00503984 · TERMINATED · funding business
  “Withdrawal of Funding”
• EVENT: Hydrotherapy and Deep Venous Thrombosis
  NCT00348907 · TERMINATED · slow accrual
  “decision to stop the study because of enrollment difficulties.”
• Comparison of Low-dose Epidural With Intravenous Narcotic Versus Intravenous Narcotic Alone
  NCT00287326 · TERMINATED · logistics pi
  “terminated by PI”
• A Study of Rofecoxib in the Treatment of Post-Operative Pain After Total Knee Joint Replacement (0966-259)
  NCT00140920 · TERMINATED · regulatory
  “Recruitment/study discontinued after withdrawal of marketing authorisation. No data entered.”
• Nicotine in Treating "Hunger Pain" in Patients With Malignant Bowel Obstruction Caused By Cancer
  NCT00425906 · WITHDRAWN · slow accrual
  “No patient enrollment occurred.”
• Prevalence of Secondary Hypogonadism in Male Patients on Chronic Opioid Therapy for Cancer-Related Pain Syndromes
  NCT00529230 · TERMINATED · slow accrual
  “Low accrual rate.”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.