Osteoarthritis

Why trials studying Osteoarthritis stopped, in this sample of ClinicalTrials.gov.

28 stopped trials with a clear reason; 93% ended for non-scientific reasons.

Trials

• Stromal Vascular Fraction (SVF) for Knee Post-Trauma Osteoarthritis (PTOA)
  NCT05515523 · WITHDRAWN · funding business
  “Lack of Funding”
• Effect of Semiconductor Embedded Therapeutic Gloves for Hand Osteoarthritis
  NCT06744855 · TERMINATED · slow accrual
  “Not enough patients interested at the site”
• PINNACLE® DM RSA Study
  NCT05357664 · TERMINATED · funding business
  “Business decision made not to fund study”
• Study of Efficacy, Safety, and Tolerability of LNA043 in Patients With Knee Osteoarthritis
  NCT04864392 · TERMINATED · funding business
  “Study early terminated due to lack of effect (did not meet primary/ secondary endpoints). This decision was not linked to safety concerns”
• Post-market Follow up Study of the 'BPK-S Integration' UC as Primary Implant in the Variants CoCr or Ceramic
  NCT03293719 · TERMINATED · logistics pi
  “Monocentric Study, Site reorganised, could no longer participate in study”
• Effectiveness of Manual Therapy and Exercise in Shoulder OA
  NCT02587559 · WITHDRAWN · slow accrual
  “Could not recruit subjects as they routinely chose surgical option”
• Fixed Bearing Versus Mobile Bearing Patient Satisfaction and Clinical Outcome Study
  NCT02633085 · WITHDRAWN · slow accrual
  “Lack of enrollment”
• Effects of Lacosamide on Post-operative Opioid Requirements After a Total Hip Arthroplasty:
  NCT02342977 · WITHDRAWN · slow accrual
  “We were unable to enroll any patients into the study.”
• Study Comparing Fit of the iTotal Versus Standard Total Knee Implants
  NCT01861028 · TERMINATED · slow accrual
  “Not enough patient volume to continue the study.”
• CoMplete™ Acetabular Hip System
  NCT01543230 · TERMINATED · funding business
  “Sponsor withdrew PMA”
• Post-Market Study of the EPIK Knee System
  NCT01464632 · WITHDRAWN · slow accrual
  “Unable to enroll any study participants.”
• Patient Education Program for Osteoarthritis With Exercise Included
  NCT01119547 · WITHDRAWN · logistics pi
  “Investigator no longer at LU.”
• Vanguard Knee Anterior Stabilized Versus Posterior Stabilized Bearing Study
  NCT01308515 · WITHDRAWN · slow accrual
  “Could not find interested researchers/clinicians to complete study protocol.”
• Evaluation of Effectiveness and Tolerability of Tapentadol Hydrochloride in Subjects With Severe Pain Due to Osteoarthritis Taking WHO Step III Analgesics But Showing a Lack of Tolerability.
  NCT00982280 · TERMINATED · slow accrual
  “Slow Recruitment and supply of Investigational Medicinal Product Issues”
• Trilogy AB Acetabular Hip System Post Approval Study
  NCT00715026 · TERMINATED · funding business
  “Sponsor business decision unrelated to clinical performance.”
• Efficacy of the CLP® Hip - Retrospective
  NCT00764842 · TERMINATED · slow accrual
  “Enrollment and data collection insufficient to continue study.”
• Foundation Knee Study - Retrospective
  NCT00764894 · TERMINATED · slow accrual
  “Enrollment and data collection insufficient to continue study.”
• A 2 Week Blinded Study For Pain Due To Arthritis Of The Knee
  NCT00483977 · TERMINATED · futility
  “Met criteria for study futility at interim analysis”
• A Single Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement
  NCT00872222 · TERMINATED · funding business
  “Study terminated early due to business reasons”
• A Two Centre Study to Assess the Stability and Long-term Performance of the C-Stem™ AMT in a Total Primary Hip Replacement
  NCT00872573 · TERMINATED · logistics pi
  “Technical issues with RSA at main site and departure of Principal Investigator”
• A Multi-centre Study to Assess the Long-term Performance of the DePuy PROXIMA™ Hip in Primary Total Hip Replacement
  NCT00208455 · TERMINATED · funding business
  “DePuy discontinued this product in 2013, the clinical program was reviewed and this Study was closed.”
• Safety and Efficacy of Buprenorphine Transdermal System (BTDS) in Subjects With Moderate to Severe Osteoarthritis Pain
  NCT00312221 · TERMINATED · logistics pi
  “terminated early for administrative reasons unrelated to safety or efficacy”
• The Press Fit Condylar (P.F.C.) Sigma Rotating Platform (RP) TC3 Revision Knee in Revision Knee Arthroplasty
  NCT00733681 · TERMINATED · other
  “Subjects were no longer able to remain compliant with follow-up intervals”
• Ascension® Post- Approval Study; PyroCarbon Metacarpophalangeal Total Joint Prosthesis
  NCT02408471 · TERMINATED · funding business
  “Business Priorities”
• A Clinical Investigation of the M2a- 38™ Hip System
  NCT00698503 · TERMINATED · slow accrual
  “due to low follow up”
• A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip Replacement
  NCT00208468 · TERMINATED · funding business
  “Slow recruitment, investigators not wishing to continue with randomisation and a decision to rationalise this product from the Sponsors portfolio.”
• A Comparison Between Titanium Femoral Stem and Cobalt-Chromium Femoral Stem in Cemented Hip Arthroplasty
  NCT00120952 · WITHDRAWN · funding business
  “No funding”
• A Comparison of Fixation Method in Total Knee Arthroplasty - Low Viscosity Versus High Viscosity Bone Cement
  NCT00175162 · WITHDRAWN · funding business
  “No financing possible”

Reasons are labeled automatically and are unverified. See the methodology. This is research information, not medical advice. Search the full database.